Adrenomyeloneuropathy (AMN) is the most frequent metabolic hereditary spastic paraplegia. Accordingly, its main site of pathological changes is the spinal cord. It is difficult to quantify AMN progression, because commonly used clinical scales have limitations, and reliable biomarkers are lacking. Our goal was to investigate whether spinal cord and brain quantitative MRI may assess structural changes in AMN over a relatively short-time period.
Longitudinal quantitative MRI in adrenomyeloneuropathy / Politi, Letterio S; Castellano, Antonella; Papinutto, Nico; Mauro, Elena; Pareyson, Davide; Henry, Roland G; Falini, Andrea; Salsano, Ettore. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - (2019). [Epub ahead of print] [10.1111/ene.13959]
Longitudinal quantitative MRI in adrenomyeloneuropathy
Castellano, AntonellaCo-primo
;Falini, Andrea;
2019-01-01
Abstract
Adrenomyeloneuropathy (AMN) is the most frequent metabolic hereditary spastic paraplegia. Accordingly, its main site of pathological changes is the spinal cord. It is difficult to quantify AMN progression, because commonly used clinical scales have limitations, and reliable biomarkers are lacking. Our goal was to investigate whether spinal cord and brain quantitative MRI may assess structural changes in AMN over a relatively short-time period.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
