Bone marrow (BM) is as an alternative site for islet transplantation, but it is not an immunoprotected microenvironment and allogeneic islets are rejected. However, the BM, for its structure and anatomic position, offers the possibility to modulate microenvironment by local interventions. We here investigate whether local irradiation is able to improve islet engraftment and prevent rejection in BM in the absence of immunosuppression.
Selective local irradiation improves islet engraftment and survival in intra–bone marrow islet transplantation / Pellegrini, S.; Cantarelli, E.; Citro, A.; Incerti, E.; Piemonti, L.; Sordi, V.. - In: CYTOTHERAPY. - ISSN 1465-3249. - (2019). [Epub ahead of print] [10.1016/j.jcyt.2019.07.005]
Selective local irradiation improves islet engraftment and survival in intra–bone marrow islet transplantation
PIEMONTI L.
Ultimo
;
2019-01-01
Abstract
Bone marrow (BM) is as an alternative site for islet transplantation, but it is not an immunoprotected microenvironment and allogeneic islets are rejected. However, the BM, for its structure and anatomic position, offers the possibility to modulate microenvironment by local interventions. We here investigate whether local irradiation is able to improve islet engraftment and prevent rejection in BM in the absence of immunosuppression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
