An unconventional population of CD4+SLAMF7+cytotoxic TEMcells (CD4+CTLs) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first line therapeutic approach in patients with IgG4-RD but their mechanism of action in this specific condition remains unknown. Here we describe the impact of glucocorticoids on CD4+CTLs in IgG4-RD.
A CD8α− Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment / Della-Torre, E., Bozzalla-Cassione, E., Sciorati, C., Ruggiero, E., Lanzillotta, M., Bonfiglio, S., Mattoo, H., Perugino, C.A., Bozzolo, E., Rovati, L., Arcidiacono, P.G., Balzano, G., Lazarevic, D., Bonini, C., Falconi, M., Stone, J.H., Dagna, L., Pillai, S., Manfredi, A.A., DELLA TORRE, E.. - In: ARTHRITIS & RHEUMATOLOGY. - ISSN 2326-5191. - (2018). [Epub ahead of print] [10.1002/art.40469]
A CD8α− Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment
Lanzillotta, Marco;Arcidiacono, Paolo Giorgio;Bonini, Chiara;Falconi, Massimo;Dagna, Lorenzo;Manfredi, Angelo A;DELLA TORRE , EMANUEL
2018-01-01
Abstract
An unconventional population of CD4+SLAMF7+cytotoxic TEMcells (CD4+CTLs) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first line therapeutic approach in patients with IgG4-RD but their mechanism of action in this specific condition remains unknown. Here we describe the impact of glucocorticoids on CD4+CTLs in IgG4-RD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
