An unconventional population of CD4+SLAMF7+cytotoxic TEMcells (CD4+CTLs) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first line therapeutic approach in patients with IgG4-RD but their mechanism of action in this specific condition remains unknown. Here we describe the impact of glucocorticoids on CD4+CTLs in IgG4-RD.
A CD8α− Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment / Della-Torre, Emanuel; Bozzalla-Cassione, Emanuele; Sciorati, Clara; Ruggiero, Eliana; Lanzillotta, Marco; Bonfiglio, Silvia; Mattoo, Hamid; Perugino, Cory A; Bozzolo, Enrica; Rovati, Lucrezia; Arcidiacono, Paolo Giorgio; Balzano, Gianpaolo; Lazarevic, Dejan; Bonini, Chiara; Falconi, Massimo; Stone, John H; Dagna, Lorenzo; Pillai, Shiv; Manfredi, Angelo A; DELLA TORRE, Emanuel. - In: ARTHRITIS & RHEUMATOLOGY. - ISSN 2326-5191. - (2018). [Epub ahead of print] [10.1002/art.40469]
A CD8α− Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment
Lanzillotta, Marco;Arcidiacono, Paolo Giorgio;Bonini, Chiara;Falconi, Massimo;Dagna, Lorenzo;Manfredi, Angelo A;DELLA TORRE , EMANUEL
2018-01-01
Abstract
An unconventional population of CD4+SLAMF7+cytotoxic TEMcells (CD4+CTLs) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first line therapeutic approach in patients with IgG4-RD but their mechanism of action in this specific condition remains unknown. Here we describe the impact of glucocorticoids on CD4+CTLs in IgG4-RD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
