Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunological fecal occult blood test (iFOBT) and calprotectin for colorectal cancer (CRC) and adenoma detection.
A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection / Kalimutho, M; Del Vecchio Blanco, G; Cretella, M; Mannisi, E; Sileri, P; Formosa, A; Pallone, F; Federici, G; Bernardini, S. - In: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. - ISSN 0179-1958. - 26:5(2011), pp. 583-592. [10.1007/s00384-010-1128-x]
A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection
Sileri P;
2011-01-01
Abstract
Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunological fecal occult blood test (iFOBT) and calprotectin for colorectal cancer (CRC) and adenoma detection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
