Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.
A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8 / Nardelli, F.; Ghitti, M.; Quilici, G.; Gori, A.; Luo, Q.; Berardi, A.; Sacchi, A.; Monieri, M.; Bergamaschi, G.; Bermel, W.; Chen, F.; Corti, A.; Curnis, F.; Musco, G.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 55:98(2019), pp. 14777-14780. [10.1039/c9cc08518a]
A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8
Corti A.
;
2019-01-01
Abstract
Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
