Aim: Chlorhexidine (CHX) is commonly used in clinical applications, including plaque control and gingivitis treatment. The im of this study was to evaluate the clinical properties, in terms of plaque control, bleeding and discoloration levels, of six CHX mouthwashes that differ in the following characteristics: CHX concentration, presence/absence of alcohol and presence/absence of an antidiscoloration system (ADS). Materials and methods: A single-center, prospective, double-blind randomized clinical trial was carried out on 78 consecutive patients. Six mouthwashes (CHX 0.12% alcohol free; CHX 0.20% alcohol free; CHX 0.12% alcohol free with ADS ; CHX 0.20% alcohol free with ADS ; CHX 0.12% with alcohol; CHX 0.20% with alcohol) were tested. Plaque Index (PI) and Bleedind Index (BI) were recorded, along with tooth staining (spectrophotometry) at T0 (beginning), at T1 (after 7 days), at T2 (after 14 days), and T3 (after 21 days). Data obtained were subjected to statistical analysis. Results: All CHX mouthwashes significantly reduced PI (p<0.0001), while only alcohol free CHX 0.20% significantly reduced BI (p<0.0001). Only the CHX 0.12% with alcohol and CHX 0.20% with alcohol mouthwashes showed a significant presence of extrinsic tooth staining (p<0.05). Conclusions: Within the limitations of the present study, the alcohol-free mouthwash CHX 0.20% allows a good control of the clinical indices, in particular the bleeding index.

Antibacterial properties and side effects of chlorhexidinebased mouthwashes. A prospective, randomized clinical study

Pantaleo G.;Gastaldi G.;Cappare P.;Gherlone E.
2020-01-01

Abstract

Aim: Chlorhexidine (CHX) is commonly used in clinical applications, including plaque control and gingivitis treatment. The im of this study was to evaluate the clinical properties, in terms of plaque control, bleeding and discoloration levels, of six CHX mouthwashes that differ in the following characteristics: CHX concentration, presence/absence of alcohol and presence/absence of an antidiscoloration system (ADS). Materials and methods: A single-center, prospective, double-blind randomized clinical trial was carried out on 78 consecutive patients. Six mouthwashes (CHX 0.12% alcohol free; CHX 0.20% alcohol free; CHX 0.12% alcohol free with ADS ; CHX 0.20% alcohol free with ADS ; CHX 0.12% with alcohol; CHX 0.20% with alcohol) were tested. Plaque Index (PI) and Bleedind Index (BI) were recorded, along with tooth staining (spectrophotometry) at T0 (beginning), at T1 (after 7 days), at T2 (after 14 days), and T3 (after 21 days). Data obtained were subjected to statistical analysis. Results: All CHX mouthwashes significantly reduced PI (p<0.0001), while only alcohol free CHX 0.20% significantly reduced BI (p<0.0001). Only the CHX 0.12% with alcohol and CHX 0.20% with alcohol mouthwashes showed a significant presence of extrinsic tooth staining (p<0.05). Conclusions: Within the limitations of the present study, the alcohol-free mouthwash CHX 0.20% allows a good control of the clinical indices, in particular the bleeding index.
2020
Chlorhexidine; Mouthwashes; Oral cancer; Tooth staining
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/99834
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