IRIS
6.1 Brevetto
 Distribuzione geografica
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Continente #
AS - Asia 2.874
NA - Nord America 1.622
EU - Europa 1.360
SA - Sud America 771
AF - Africa 47
Totale 6.674
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Nazione #
US - Stati Uniti d'America 1.544
SG - Singapore 1.284
CN - Cina 816
BR - Brasile 640
SE - Svezia 626
HK - Hong Kong 380
VN - Vietnam 229
IT - Italia 190
DE - Germania 148
RU - Federazione Russa 143
FI - Finlandia 108
IN - India 51
AR - Argentina 50
CA - Canada 42
GB - Regno Unito 31
MX - Messico 25
ZA - Sudafrica 25
EC - Ecuador 24
CO - Colombia 23
ID - Indonesia 22
PL - Polonia 20
FR - Francia 19
BD - Bangladesh 18
NL - Olanda 18
IQ - Iraq 14
AT - Austria 11
PY - Paraguay 10
ES - Italia 9
IR - Iran 9
RO - Romania 9
MA - Marocco 8
TR - Turchia 8
UA - Ucraina 8
CL - Cile 6
UY - Uruguay 6
AE - Emirati Arabi Uniti 5
JP - Giappone 5
VE - Venezuela 5
EG - Egitto 4
IE - Irlanda 4
IL - Israele 4
KE - Kenya 4
KZ - Kazakistan 4
PE - Perù 4
PK - Pakistan 4
BO - Bolivia 3
CH - Svizzera 3
CZ - Repubblica Ceca 3
JM - Giamaica 3
JO - Giordania 3
OM - Oman 3
AM - Armenia 2
AZ - Azerbaigian 2
DO - Repubblica Dominicana 2
LT - Lituania 2
RS - Serbia 2
SA - Arabia Saudita 2
TN - Tunisia 2
TW - Taiwan 2
UZ - Uzbekistan 2
AL - Albania 1
BE - Belgio 1
BH - Bahrain 1
CG - Congo 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
DM - Dominica 1
EE - Estonia 1
ET - Etiopia 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
LB - Libano 1
MK - Macedonia 1
MY - Malesia 1
PA - Panama 1
SI - Slovenia 1
SN - Senegal 1
SY - Repubblica araba siriana 1
TL - Timor Orientale 1
TT - Trinidad e Tobago 1
Totale 6.674
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Città #
Dallas 548
Singapore 416
Hong Kong 378
Shanghai 240
Hefei 173
Beijing 151
Lawrence 136
Princeton 136
Ashburn 132
Ho Chi Minh City 85
Helsinki 83
São Paulo 53
Hanoi 43
Milan 41
New York 40
Los Angeles 39
Munich 34
Washington 27
Turku 24
Boardman 23
Bologna 23
Pune 23
Ancona 22
Guangzhou 18
Warsaw 18
Rio de Janeiro 17
Montreal 16
Moscow 16
Nuremberg 16
Brasília 14
Curitiba 14
Rome 14
Brooklyn 13
Da Nang 13
Denver 13
Guarulhos 13
Johannesburg 13
Stockholm 13
Toronto 12
Guayaquil 11
Hải Dương 11
Poplar 11
Haiphong 10
Perugia 10
Campinas 9
Mexico City 9
London 8
Orem 8
Turin 8
Amsterdam 7
Baghdad 7
Cape Town 7
Chennai 7
Dhaka 7
Houston 7
Nova Iguaçu 7
Porto Alegre 7
Quito 7
Santa Clara 7
Shenzhen 7
Tianjin 7
Bogotá 6
Falkenstein 6
Frankfurt am Main 6
Phoenix 6
Piracicaba 6
Salvador 6
São Bernardo do Campo 6
Asunción 5
Atlanta 5
Fortaleza 5
Montevideo 5
Santiago de Cali 5
Santo André 5
Tehran 5
Thái Bình 5
Thái Nguyên 5
Tokyo 5
Betim 4
Bloomington 4
Buenos Aires 4
Canoas 4
Charlotte 4
Chicago 4
Conselheiro Lafaiete 4
Contagem 4
Dublin 4
Duque de Caxias 4
Goiânia 4
Haining 4
Hangzhou 4
Ipatinga 4
Lima 4
Limeira 4
Manaus 4
Manchester 4
Maringá 4
Mauá 4
Nairobi 4
Ottawa 4
Totale 3.462
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Nome #
System for physical activity, and related method 212
[Severe aortic stenosis successfully treated with percutaneous aortic valve implantation] 121
Ablation catheter with flexible tip and methods of making the same 87
2) HERV-H per l'uso come marcatore molecolare del Disturbo dello Spettro Autistico e relativo metodo diagnostico in vitro, kit diagnostico e usi medici (2012).GAUDI S F 82
Permanent Epigenetic Gene Silencing 81
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 76
Sistema per svolgere attività fisica, e relativo procedimento 72
COMPOSITIONS AND METHODS FOR EPIGENETIC REGULATION OF HBV GENE EXPRESSION 69
RECOMBINANT LENTIVIRAL VECTOR FOR STEM CELL-BASED GENE THERAPY OF SICKLE CELL DISORDER 68
ACETYLATED HMGB1 PROTEIN 68
GENE SILENCING 66
HMGB1 inhibitors and antagonista for the inhibition of atherosclerosis pathogenesis and development 65
Use of HMGB2 and HMGB3 proteins for medical applications 64
VIRAL VECTOR COMBINING GENE THERAPY AND GENOME EDITING APPROACHES FOR GENE THERAPY OF GENETIC DISORDERS 63
INCREASE OF MYELOID MICROVESICLES IN THE CEREBROSPINAL FLUID AS BIOMARKER OF MICROGLIA/MACROPHAGE ACTIVATION IN NEUROLOGICAL DISORDERS 63
Dispositivo di cannulazione vascolare 61
Treatment and Prevention of Cancer with HMGB1 Antagonists 60
Novel biomarkers 59
HMGB1 protein inhibitors for the regulation of smooth muscle cells and endothelial cells proliferation 59
Adjuvant incorporation in immunoanotherapeutics 55
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 54
VECTOR PRODUCTION 53
PROCEDIMENTO E SISTEMA PER LA RILEVAZIONE DI RISPOSTE BINARIE TRAMITE ANALISI DEL DIAMETRO PUPILLARE DI UN SOGGETTO 52
Formulations to administer SUMO2/3 51
Spinginodo 48
Methods and compositions for targeted integration 48
Agents regulating vascular permeability 47
Human monoclonal recombinant antibody against NS3 HCV protein and methods therefor 46
Anti-HCV monoclonal antibody as a medicament for the therapeutic treatment and prevention of HCV infections 46
Inhibitors of hepatitis B virus 45
Method for the preparation of new oligoclonal antibodies 44
Receptor-antibody sandwich assay. 44
“Non-invasive ventilation mask and use thereof” 44
Structure and function of the salicyclic acid binding sites on human hmgb1 and methods of use thereof for the rational design of both salicyclic acid derivatives and other agents that alter animal and plant hmgbs activities 44
Anti-urokinase monoclonal antibody, matrix bearing it, test method, biochemical test kits which use it. 43
Use of IL-7 and IL-15 for the genetic modification of memory T lymphocytes 43
Collagen Scaffold in nervous system regeneration 42
Anti-idiotype monoclonal antibodies as mimotopes of the HIV gp120 antigen 42
Tricuspid valve repair using tension 42
Control for a Remote Navigation System 42
DISPOSITIVO PER USO IN EMODINAMICA 42
MEZZO PER VEDERE UNA VALVOLA CARDIACA IN FASE INTRAOPERATORIA 42
SULFONAMIDES USEFUL IN THE PREVENTION OF DIABETES 41
Phage Display Technology 41
Hmgb1 variants and uses thereof 41
Method of treating cardiac arrhythmias 41
System and methods for locating and ablating arrhythomogenic tissues 41
Cyclic inhibitors of hepatitis B virus 41
Cytokine conjugates (IL-12 –peptide conjugates) 40
Method and apparatus for tricuspid valve repair using tension 40
Anti-idiotype monoclonal antibody directed against anti-TNF antibodies 40
Vaccine nanotechnology 40
INFLUENZA VIRUS AND TYPE 1 DIABETES 40
Suturatrice automatica per borsa di tabacco 39
Methods for treating cardiac reperfusion injury 39
Magnetically Guided Catheter With Flexible Tip 39
Human Monoclonal Antibody Fab Fragments directed against HCV E2 glycoprotein and endowed with neutralizing activity 38
Solid-phase receptor assay for antibiotics of the vancomycin class. 38
Immunonanotherapeutics that provide IgG humoral response without T-cell antigen 38
PROTESI ANULARE PER VALVOLA MITRALE 38
Delivery tool for implantation of spool assembly coupled to a helical anchor 38
Suturatrice meccanica circolare 37
Dispositivo anastomotico ad anelli 37
Suturatrice automatica per borsa di tabacco 37
Dispositivo ad anelli frammentabili 37
Dispositivo per la chirurgia endoscopica transanale 37
Anticorpo monoclonale diretto contro il virus JC 37
System and Network for Remote Medical Procedures 37
Irrigated Catheter with Improved fluid flow 37
Multi-Electrode Irrigated Balloon Catheter 37
Tricyclic inhibitors of hepatitis B virus 37
Suturatrice meccanica circolare 36
Dispositivo anastomotico ad anelli 36
Monoclonal antibodies as a medicament for the therapeutic and/or prophylactic treatment of swine-origin influenza A (H1N1) virus (S-OIV) infections 36
Anti-HCV monoclonal antibody as a medicament for the therapeutic treatment and prevention of HCV infections 36
Nicotine immunonanotherapeutics 36
STK4 inhibitors for treatment of hematological malignancies 36
CARDIAC TISSUE CINCHING 36
Real heart case simulator 36
INHIBITORS OF CXCR1/2 AS ADJUVANTS IN THE TRANSPLANT OF PANCREATIC ISLETS 35
Réparation de valve tricuspide à l'aide d'une tension 35
Use of HMGB1 and analogues thereof for wound healing 35
Modified cytokines for therapeutic use 35
Cromogranina A per uso come reagente in un metodo diagnostico o prognostico 35
Use of common gamma-chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes 35
Targeting of antigen presenting cells with immunonanotherapeutics 35
RETAINING MECHANISMS FOR PROSTHETIC VALVES 35
FOSSA OVALIS PENETRATION APPARATUS 35
Bottone anastomotico frammentabile 34
HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases 34
Combination product (Use of IDO inhibitors in cancer therapy with targeted interferon gamma) 34
Strumento automatico per suture a borsa di tabacco 34
Immobilized oligopeptides 34
Selective immunoassay for the detection of pro-urokinase and urokinase 34
Circulating chromogranin A 34
Novel Targets in Multiple Myeloma and Other Disorders 34
PERCUTANEOUS TETHER LOCKING 34
HUMAN MONOCLONAL ANTIBODIES TO HERPES SIMPLEX VIRUS AND METHODS THEREFOR 33
Monoclonal antibodies having homosubtype cross-neutralization properties against influenza A viruses subtype H1 33
Monoclonal antibodies against the TNF type-I receptor, process for their production and use thereofAnticorpi monoclonali anti-recettore di tipo 1 del TNF alfa, procedimento per la loro produzione e loro uso 33
Totale 4.686
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211 0 0 0 0 0 0 0 0 0 0 1 0
2021/2022142 4 0 0 84 4 4 3 9 10 12 6 6
2022/2023933 299 260 109 3 1 113 8 36 58 11 15 20
2023/2024473 40 11 132 32 23 46 12 29 0 31 12 105
2024/20252.186 259 38 61 86 33 166 320 158 351 224 252 238
2025/20262.991 480 602 500 898 474 37 0 0 0 0 0 0
Totale 6.752