Background: Early-onset Colorectal Cancer (eoCRC), defined as a CRC in patients younger than 50 years old, shows an increasing incidence worldwide in the latest years. The role of exogenous factors associated with CRC has been largely overlooked in eoCRC. Here, we conducted a case-control study to evaluate the diet and the lifestyle habits in an Italian population of patients with eoCRC, compared to age-matched healthy controls (HCs). Methods: We enrolled 118 subjects (47 cases, 71 controls) in a third-level academic hospital. We analyzed epidemiological features (age, sex, BMI), lifestyle behaviors (smoking habits, physical activity, type of diet, use of dietary supplements), and eating habits (semi-quantitative food-frequency questionnaire) in eoCRCs and HCs, covering the previous 5 years. Results: In our cohort, positive family history of CRC was significantly associated with the development of eoCRC (p=0.004). Fresh meat (p=0.003), processed meat (p<0.001), dairy products (p=0.013), and smoking (p=0.0001) were significantly associated with eoCRC compared to controls. Other variables did not differ significantly between the two groups. Conclusion: Fresh and processed meat, dairy products, and smoking could be considered significant risk factors for eoCRC, although further confirmation by international multicenter studies is desirable. Diet and smoking could be the main areas of future interventions for eoCRC primary prevention.

DIET AND LIFESTYLE HABITS IN EARLY-ONSET COLORECTAL CANCER. A PILOT CASE-CONTROL STUDY / Puzzono, Marta; Mannucci, Alessandro; Di Leo, Milena; Zuppardo, Raffaella A; Russo, Michele; Ditonno, Ilaria; Goni, Elisabetta; Notaristefano, Chiara; Azzolini, Francesco; Fanti, Lorella; Viale, Edi; Elmore, Ugo; Pantaleo, Giuseppe; Cascinu, Stefano; Rosati, Riccardo; Cavestro, Giulia Martina. - In: DIGESTIVE DISEASES. - ISSN 0257-2753. - 40:6(2022), pp. 710-718. [10.1159/000521932]

DIET AND LIFESTYLE HABITS IN EARLY-ONSET COLORECTAL CANCER. A PILOT CASE-CONTROL STUDY

Mannucci, Alessandro
Secondo
;
Elmore, Ugo;Pantaleo, Giuseppe;Cascinu, Stefano;Rosati, Riccardo
Penultimo
;
Cavestro, Giulia Martina
Ultimo
2022-01-01

Abstract

Background: Early-onset Colorectal Cancer (eoCRC), defined as a CRC in patients younger than 50 years old, shows an increasing incidence worldwide in the latest years. The role of exogenous factors associated with CRC has been largely overlooked in eoCRC. Here, we conducted a case-control study to evaluate the diet and the lifestyle habits in an Italian population of patients with eoCRC, compared to age-matched healthy controls (HCs). Methods: We enrolled 118 subjects (47 cases, 71 controls) in a third-level academic hospital. We analyzed epidemiological features (age, sex, BMI), lifestyle behaviors (smoking habits, physical activity, type of diet, use of dietary supplements), and eating habits (semi-quantitative food-frequency questionnaire) in eoCRCs and HCs, covering the previous 5 years. Results: In our cohort, positive family history of CRC was significantly associated with the development of eoCRC (p=0.004). Fresh meat (p=0.003), processed meat (p<0.001), dairy products (p=0.013), and smoking (p=0.0001) were significantly associated with eoCRC compared to controls. Other variables did not differ significantly between the two groups. Conclusion: Fresh and processed meat, dairy products, and smoking could be considered significant risk factors for eoCRC, although further confirmation by international multicenter studies is desirable. Diet and smoking could be the main areas of future interventions for eoCRC primary prevention.
2022
Colorectal cancer, Diet, Early-onset colorectal cancer, Lifestyle, Risk factors
File in questo prodotto:
File Dimensione Formato  
diet and lifestyle.pdf

solo gestori archivio

Tipologia: PDF editoriale (versione pubblicata dall'editore)
Licenza: Copyright dell'editore
Dimensione 3.91 MB
Formato Adobe PDF
3.91 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/123598
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact