The aim of the present study is to investigate and compare the performances of68Ga-PSMA and68Ga-DOTA-RM2 PET/MRI in identifying recurrent prostate cancer (PCa) after primary treatment and to explore the association of dual-tracer PET findings with clinical and histopathological characteristics. Thirty-five patients with biochemical relapse (BCR) of PCa underwent68Ga PSMA PET/MRI for restaging purpose, with 31/35 also undergoing68Ga-DOTA-RM2 PET/MRI scan within 16 days (mean: 3 days, range: 2–16 days). Qualitative and quantitative image analysis has been performed by comparing68Ga-PSMA and68Ga-DOTA-RM2 PET/MRI findings both on a patient and lesion basis. Clinical and instrumental follow-up was used to validate PET findings. Fisher’s exact test and Mann-Whitney U test were used to investigate the association between dual-tracer PET findings, clinical and histopathological data. p-value significance was defined below the 0.05 level. Patients’ mean age was 70 years (range: 49–84) and mean PSA at time of PET/MR scans was 1.88 ng/mL (range: 0.21–14.4). A higher detection rate was observed for68Ga-PSMA PET/MRI, with more lesions being detected compared to68Ga-DOTA-RM2 PET/MRI (26/35 patients, 95 lesions vs. 15/31 patients, 41 lesions; p = 0.016 and 0.002).68Ga-PSMA and68Ga-DOTA-RM2 PET/MRI findings were discordant in 11/31 patients; among these, 10 were68Ga-PSMA positive (9/10 confirmed as true positive and 1/10 as false positive by follow-up examination). Patients with higher levels of PSA and shorter PSA doubling time (DT) presented more lesions on68Ga-PSMA PET/MRI (p = 0.006 and 0.044), while no association was found between PET findings and Gleason score.68Ga-PSMA has a higher detection rate than68Ga-DOTA-RM2 in detecting PCa recurrence. The number of68Ga-PSMA PET positive lesions is associated with higher levels of PSA and shorter PSA DT, thus representing potential prognostic factors.
68Ga-PSMA and 68Ga-DOTA-RM2 PET/MRI in Recurrent Prostate Cancer: Diagnostic Performance and Association with Clinical and Histopathological Data / Mapelli, P.; Ghezzo, S.; Samanes Gajate, A. M.; Preza, E.; Palmisano, A.; Cucchiara, V.; Brembilla, G.; Bezzi, C.; Rigamonti, R.; Magnani, P.; Toninelli, E.; Bettinardi, V.; Suardi, N.; Gianolli, L.; Scifo, P.; Briganti, A.; De Cobelli, F.; Esposito, A.; Picchio, M.. - In: CANCERS. - ISSN 2072-6694. - 14:2(2022), p. 334. [10.3390/cancers14020334]
68Ga-PSMA and 68Ga-DOTA-RM2 PET/MRI in Recurrent Prostate Cancer: Diagnostic Performance and Association with Clinical and Histopathological Data
Mapelli P.;Ghezzo S.;Palmisano A.;Cucchiara V.;Brembilla G.;Bezzi C.;Briganti A.;De Cobelli F.;Esposito A.;Picchio M.
2022-01-01
Abstract
The aim of the present study is to investigate and compare the performances of68Ga-PSMA and68Ga-DOTA-RM2 PET/MRI in identifying recurrent prostate cancer (PCa) after primary treatment and to explore the association of dual-tracer PET findings with clinical and histopathological characteristics. Thirty-five patients with biochemical relapse (BCR) of PCa underwent68Ga PSMA PET/MRI for restaging purpose, with 31/35 also undergoing68Ga-DOTA-RM2 PET/MRI scan within 16 days (mean: 3 days, range: 2–16 days). Qualitative and quantitative image analysis has been performed by comparing68Ga-PSMA and68Ga-DOTA-RM2 PET/MRI findings both on a patient and lesion basis. Clinical and instrumental follow-up was used to validate PET findings. Fisher’s exact test and Mann-Whitney U test were used to investigate the association between dual-tracer PET findings, clinical and histopathological data. p-value significance was defined below the 0.05 level. Patients’ mean age was 70 years (range: 49–84) and mean PSA at time of PET/MR scans was 1.88 ng/mL (range: 0.21–14.4). A higher detection rate was observed for68Ga-PSMA PET/MRI, with more lesions being detected compared to68Ga-DOTA-RM2 PET/MRI (26/35 patients, 95 lesions vs. 15/31 patients, 41 lesions; p = 0.016 and 0.002).68Ga-PSMA and68Ga-DOTA-RM2 PET/MRI findings were discordant in 11/31 patients; among these, 10 were68Ga-PSMA positive (9/10 confirmed as true positive and 1/10 as false positive by follow-up examination). Patients with higher levels of PSA and shorter PSA doubling time (DT) presented more lesions on68Ga-PSMA PET/MRI (p = 0.006 and 0.044), while no association was found between PET findings and Gleason score.68Ga-PSMA has a higher detection rate than68Ga-DOTA-RM2 in detecting PCa recurrence. The number of68Ga-PSMA PET positive lesions is associated with higher levels of PSA and shorter PSA DT, thus representing potential prognostic factors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
