Background:The dorsal anterior cingulate cortex (dACC) is a key network hub for cognitive control and environmental adaptation. Previous studies have shown that task-based functional activity in this area is constrained by individual differences in sulcal pattern, a morphologic feature of cortex anatomy determined during fetal life and stable throughout development.Methods:By using anatomical magnetic resonance imaging and seed-based resting-state functional connectivity (rsFC), we explored the influence of sulcal pattern variability on the functional architecture of the dACC in a sample of healthy adults aged 20-80 years (n = 173).Results:Overall, rsFC was associated with individual differences in sulcal pattern. Furthermore, rsFC was modulated by the age-sulcal pattern interaction.Conclusion:Our results suggest a relationship between brain structure and function that partly traces back to early stages of brain development. The modulation of rsFC by the age-sulcal pattern interaction indicates that the effects of sulcal pattern variability on the functional architecture of the dACC may change over adulthood, with potential repercussions for brain network efficiency and cognitive function in aging.

Sulcal Pattern Variability and Dorsal Anterior Cingulate Cortex Functional Connectivity Across Adult Age

Fedeli, Davide;Del Maschio, Nicola;Sulpizio, Simone;Abutalebi, Jubin
2020

Abstract

Background:The dorsal anterior cingulate cortex (dACC) is a key network hub for cognitive control and environmental adaptation. Previous studies have shown that task-based functional activity in this area is constrained by individual differences in sulcal pattern, a morphologic feature of cortex anatomy determined during fetal life and stable throughout development.Methods:By using anatomical magnetic resonance imaging and seed-based resting-state functional connectivity (rsFC), we explored the influence of sulcal pattern variability on the functional architecture of the dACC in a sample of healthy adults aged 20-80 years (n = 173).Results:Overall, rsFC was associated with individual differences in sulcal pattern. Furthermore, rsFC was modulated by the age-sulcal pattern interaction.Conclusion:Our results suggest a relationship between brain structure and function that partly traces back to early stages of brain development. The modulation of rsFC by the age-sulcal pattern interaction indicates that the effects of sulcal pattern variability on the functional architecture of the dACC may change over adulthood, with potential repercussions for brain network efficiency and cognitive function in aging.
anterior cingulate cortex
cortical morphology
paracingulate sulcus
resting-state functional connectivity
structure–function relationship
sulcal pattern
Adult
Aged
Aged, 80 and over
Aging
Brain
Brain Mapping
Cerebral Cortex
Cognition
Female
Gyrus Cinguli
Humans
Individuality
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/132703
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