Bipolar disorder (BD) is linked to several structural and functional brain alterations. In addition, BD patients have a three-fold increased risk of developing insulin resistance, which is associated with neural changes and poorer BD outcomes. Therefore, we investigated the effects of insulin and two derived measures (insulin resistance and sensitivity) on white matter (WM) microstructure, resting-state (rs) functional connectivity (FC), and fractional amplitude of low frequency fluctuation (fALFF).
Insulin resistance disrupts white matter microstructure and amplitude of functional spontaneous activity in Bipolar Disorder / Mazza, Elena; Calesella, Federico; Paolini, Marco; di Pasquasio, Camilla; Poletti, Sara; Lorenzi, Cristina; Falini, Andrea; Zanardi, Raffaella; Colombo, Cristina; Benedetti, Francesco. - In: BIPOLAR DISORDERS. - ISSN 1398-5647. - (2022). [Epub ahead of print] [10.1111/bdi.13270]
Insulin resistance disrupts white matter microstructure and amplitude of functional spontaneous activity in Bipolar Disorder
Mazza, Elena;Calesella, Federico;Paolini, Marco;Poletti, Sara;Falini, Andrea;Colombo, Cristina;Benedetti, Francesco
2022-01-01
Abstract
Bipolar disorder (BD) is linked to several structural and functional brain alterations. In addition, BD patients have a three-fold increased risk of developing insulin resistance, which is associated with neural changes and poorer BD outcomes. Therefore, we investigated the effects of insulin and two derived measures (insulin resistance and sensitivity) on white matter (WM) microstructure, resting-state (rs) functional connectivity (FC), and fractional amplitude of low frequency fluctuation (fALFF).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
