Bipolar disorder (BD) is linked to several structural and functional brain alterations. In addition, BD patients have a three-fold increased risk of developing insulin resistance, which is associated with neural changes and poorer BD outcomes. Therefore, we investigated the effects of insulin and two derived measures (insulin resistance and sensitivity) on white matter (WM) microstructure, resting-state (rs) functional connectivity (FC), and fractional amplitude of low frequency fluctuation (fALFF).

Insulin resistance disrupts white matter microstructure and amplitude of functional spontaneous activity in Bipolar Disorder

Mazza, Elena;Calesella, Federico;Paolini, Marco;Poletti, Sara;Falini, Andrea;Colombo, Cristina;Benedetti, Francesco
2022

Abstract

Bipolar disorder (BD) is linked to several structural and functional brain alterations. In addition, BD patients have a three-fold increased risk of developing insulin resistance, which is associated with neural changes and poorer BD outcomes. Therefore, we investigated the effects of insulin and two derived measures (insulin resistance and sensitivity) on white matter (WM) microstructure, resting-state (rs) functional connectivity (FC), and fractional amplitude of low frequency fluctuation (fALFF).
Bipolar Disorder
HOMA-IR
TBSS
fALFF
inflammation
insulin
white matter
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/133691
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