Background: COVID-19 patients frequently develop respiratory failure requiring mechanical ventilation. Data on long-term survival of patients who had severe COVID-19 are insufficient. We assessed and compared two-year survival, CT imaging, quality of life, and functional recovery of COVID-19 ARDS patients requiring respiratory support with invasive (IMV) versus noninvasive ventilation (NIV). Methods: Patients with COVID-19 pneumonia admitted up to May 28th, 2020, who required IMV or NIV, and survived to hospital discharge were enrolled. Patients were contacted two years after discharge to assess vital status, functional, psychological, and cognitive outcomes using validated scales. Patients with persistent respiratory symptoms or high burden of residual lung damage at previous CT scan received a two-year chest CT scan. Results: Out of 61 IMV survivors, 98% were alive at two-year follow-up, and 52 completed the questionnaire. Out of 82 survivors receiving NIV only, 94% were alive at two years, and 47 completed the questionnaire. We found no major differences between invasively and noninvasively ventilated patients, with overall acceptable functional recovery. Among the 99 patients completing the questionnaire, 23 have more than moderate exertional dyspnea. Chest CT scans showed that 4 patients (all received IMV) had fibrotic-like changes. Conclusions: Patients who received mechanical ventilation due to COVID-19 and were discharged from hospital had a 96% survival rate at the two-year follow-up. There was no difference in overall recovery and quality of life between patients who did and did not require IMV, although respiratory morbidity remains high.

Two-year multidisciplinary follow-up of COVID-19 patients requiring invasive and noninvasive respiratory support / Tresoldi, Moreno; Zangrillo, Alberto; Belletti, Alessandro; Ramirez, Giuseppe A; Bozzolo, Enrica; Guzzo, Francesca; Marinosci, Alessandro; Fominskiy, Evgeny V; DA Prat, Valentina; Marmiere, Marilena; Palumbo, Diego; Del Prete, Lidia; D'Amico, Filippo; Bellino, Chiara; Morando, Deodata; Saracino, Marco; Ortalda, Alessandro; Castelli, Elena; Rocchi, Margherita; Baiardo Redaelli, Martina; Scotti, Raffaella; DI Terlizzi, Gaetano; Azzolini, Maria L; Guaschino, Giulia; Avitabile, Emma; Borghi, Giovanni; Soddu, Daniele; Dagna, Lorenzo; Landoni, Giovanni; DE Cobelli, Francesco. - In: MINERVA MEDICA. - ISSN 1827-1669. - 114:6(2023), pp. 773-784. [10.23736/S0026-4806.22.08397-5]

Two-year multidisciplinary follow-up of COVID-19 patients requiring invasive and noninvasive respiratory support

Zangrillo, Alberto
Secondo
;
Belletti, Alessandro;Ramirez, Giuseppe A;Marmiere, Marilena;Palumbo, Diego;Del Prete, Lidia;D'Amico, Filippo;Bellino, Chiara;Morando, Deodata;Saracino, Marco;Ortalda, Alessandro;Rocchi, Margherita;Dagna, Lorenzo;Landoni, Giovanni
Penultimo
;
DE Cobelli, Francesco
2023-01-01

Abstract

Background: COVID-19 patients frequently develop respiratory failure requiring mechanical ventilation. Data on long-term survival of patients who had severe COVID-19 are insufficient. We assessed and compared two-year survival, CT imaging, quality of life, and functional recovery of COVID-19 ARDS patients requiring respiratory support with invasive (IMV) versus noninvasive ventilation (NIV). Methods: Patients with COVID-19 pneumonia admitted up to May 28th, 2020, who required IMV or NIV, and survived to hospital discharge were enrolled. Patients were contacted two years after discharge to assess vital status, functional, psychological, and cognitive outcomes using validated scales. Patients with persistent respiratory symptoms or high burden of residual lung damage at previous CT scan received a two-year chest CT scan. Results: Out of 61 IMV survivors, 98% were alive at two-year follow-up, and 52 completed the questionnaire. Out of 82 survivors receiving NIV only, 94% were alive at two years, and 47 completed the questionnaire. We found no major differences between invasively and noninvasively ventilated patients, with overall acceptable functional recovery. Among the 99 patients completing the questionnaire, 23 have more than moderate exertional dyspnea. Chest CT scans showed that 4 patients (all received IMV) had fibrotic-like changes. Conclusions: Patients who received mechanical ventilation due to COVID-19 and were discharged from hospital had a 96% survival rate at the two-year follow-up. There was no difference in overall recovery and quality of life between patients who did and did not require IMV, although respiratory morbidity remains high.
2023
COVID-19; Critical care outcomes; Quality of life; Respiration, artificial; Respiratory distress syndrome
File in questo prodotto:
File Dimensione Formato  
R10Y2023N06A0773.pdf

solo gestori archivio

Tipologia: PDF editoriale (versione pubblicata dall'editore)
Licenza: Copyright dell'editore
Dimensione 1.05 MB
Formato Adobe PDF
1.05 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/140282
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact