Background: The screening for LTB before anti-TNF therapy is mandatory. Tuberculin Skin Test (TST) and QFT Gold in tube (QFT-GIT) may help in the detection of LTB patients who submitted a prophylactic treatment. Objectives: Evaluate the role of by QFT-GIT in the evaluation of the efficacy of the LTB prophylaxis in patients affected by rheumatic disease Methods: Out of 561 patients (263 Rheumatoid Arthritis (AR), 126 Psoriatic Arthritis (PsA) and 73 Spondiloarthropaty (SpA), 5 Inflammatory Bowel Disease (IBD) and 94 with other immunomediated chronic disease), we performed TST and QFT as screening tests and QFT was performed at the end the prophylaxis. Results: After screening, LTB was diagnosed in 87 patients who were submitted to prophylaxis (Isoniazid for 9 months or Isoniazid plus Rifampicin for 3 months).We compared by analysis of variance the value of QFT index at the beginning and at the end the therapy (QFT-GIT medium value at the beginning 5.39 and 4.0 at the end). This comparison showed no statistically significant differences (significance value 0.31). Conclusions: QFT-GIT is helpful to identify LTB but our data show that QFT-GIT index is not useful to asses the efficacy of the TB prophylaxis and rule out during the follow up the TB re-infection. QFT may be useful in identifying the TB infection during the follow up of patients who were negative at the screening.
Quantiferon (QFT) identifies latent tuberculosis (LTB) but does not help the evaluation of the efficacy of prophylaxis in inflammatory arthritides / Peruzzi, F.; Bartalesi, F.; Attala, Letizia; Cavallo, Annalisa; Fiori, Ginevra; MADDALI BONGI, Susanna; Bruni, Cosimo; Nacci, Francesca; Bartoli, Francesca; Cappelli, S.; Denaro, V.; Bartoloni, Alessandro; MATUCCI CERINIC, Marco. - In: ANNALS OF THE RHEUMATIC DISEASES. - ISSN 0003-4967. - 71:(2012), pp. 664-664. (Intervento presentato al convegno EULAR Congress tenutosi a Berlin).
Quantiferon (QFT) identifies latent tuberculosis (LTB) but does not help the evaluation of the efficacy of prophylaxis in inflammatory arthritides
MATUCCI CERINIC, MARCO
2012-01-01
Abstract
Background: The screening for LTB before anti-TNF therapy is mandatory. Tuberculin Skin Test (TST) and QFT Gold in tube (QFT-GIT) may help in the detection of LTB patients who submitted a prophylactic treatment. Objectives: Evaluate the role of by QFT-GIT in the evaluation of the efficacy of the LTB prophylaxis in patients affected by rheumatic disease Methods: Out of 561 patients (263 Rheumatoid Arthritis (AR), 126 Psoriatic Arthritis (PsA) and 73 Spondiloarthropaty (SpA), 5 Inflammatory Bowel Disease (IBD) and 94 with other immunomediated chronic disease), we performed TST and QFT as screening tests and QFT was performed at the end the prophylaxis. Results: After screening, LTB was diagnosed in 87 patients who were submitted to prophylaxis (Isoniazid for 9 months or Isoniazid plus Rifampicin for 3 months).We compared by analysis of variance the value of QFT index at the beginning and at the end the therapy (QFT-GIT medium value at the beginning 5.39 and 4.0 at the end). This comparison showed no statistically significant differences (significance value 0.31). Conclusions: QFT-GIT is helpful to identify LTB but our data show that QFT-GIT index is not useful to asses the efficacy of the TB prophylaxis and rule out during the follow up the TB re-infection. QFT may be useful in identifying the TB infection during the follow up of patients who were negative at the screening.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
