: Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.
Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients / De Lorenzo, R., Loré, N.I., Finardi, A., Mandelli, A., Calesella, F., Palladini, M., Cirillo, D.M., Tresoldi, C., Ciceri, F., Rovere-Querini, P., Manfredi, A.A., Mazza, M.G., Benedetti, F., Furlan, R.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:15(2024). [10.3390/ijms25158259]
Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients
De Lorenzo R.Primo
;Calesella F.;Palladini M.;Ciceri F.;Rovere-Querini P.;Manfredi A. A.;Mazza M. G.;Benedetti F.
Penultimo
;Furlan R.Ultimo
2024-01-01
Abstract
: Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.| File | Dimensione | Formato | |
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