: Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.
Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients / De Lorenzo, R.; Loré, N. I.; Finardi, A.; Mandelli, A.; Calesella, F.; Palladini, M.; Cirillo, D. M.; Tresoldi, C.; Ciceri, F.; Rovere-Querini, P.; Manfredi, A. A.; Mazza, M. G.; Benedetti, F.; Furlan, R.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:15(2024). [10.3390/ijms25158259]
Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients
De Lorenzo R.;Calesella F.;Palladini M.;Ciceri F.;Rovere-Querini P.;Manfredi A. A.;Mazza M. G.;Benedetti F.;Furlan R.
2024-01-01
Abstract
: Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
