The lack of expression of TFEB in 12/13 cases of MVM seems to corroborate the role of TFEB in vascular remodel- ing during placental development. The positivity in VSTB and vessels in cases with mixed MVM and DVM histological features in patients with gestational diabetes may suggest that hypoxic injury is mediated through mechanisms (such as the ALANO pathway) different from those intervening in MVM despite some morpho- logical similarities.
Transcription Factor EB (TFEB) Expression and Localization in the 3rd-Trimester Preeclamptic and Diabetic Placenta / Giacometti, Cinzia; De Marchi, Francesca; Ambrosi, Alessandro; Cavaliere, Serena; Caliò, Anna; Mautone, Daniele; Martignoni, Guido. - In: LABORATORY INVESTIGATION. - ISSN 0023-6837. - 105:3(2025), pp. 45-46. ( USCAP 114th Annual Meeting: See the Light Boston (US) 22-25 marzo 2025) [10.1016/j.labinv.2024.103220].
Transcription Factor EB (TFEB) Expression and Localization in the 3rd-Trimester Preeclamptic and Diabetic Placenta
Ambrosi, Alessandro;
2025-01-01
Abstract
The lack of expression of TFEB in 12/13 cases of MVM seems to corroborate the role of TFEB in vascular remodel- ing during placental development. The positivity in VSTB and vessels in cases with mixed MVM and DVM histological features in patients with gestational diabetes may suggest that hypoxic injury is mediated through mechanisms (such as the ALANO pathway) different from those intervening in MVM despite some morpho- logical similarities.| File | Dimensione | Formato | |
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