Background: Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during executive function, we conducted a mega-analysis in the ENIGMA-OCD consortium pooling individual participant data from 475 individuals with OCD and 345 healthy control participants across 15 functional magnetic resonance imaging (fMRI) tasks collected worldwide. Methods: Individual participant data were uniformly processed using HALFpipe to construct voxelwise statistical images of executive processing and task load contrasts. Parameter estimates extracted from regions of interest were entered into multilevel Bayesian models to examine regional and whole-brain effects of diagnosis and, within OCD, the influence of medication status, symptom severity, and age of onset on task activation. Results: We observed a robust task activation pattern across individuals with OCD and control participants in executive processing regions across tasks. Relative to control participants, individuals with OCD showed moderate to very strong evidence of weaker activation of the dorsolateral prefrontal cortex, precuneus, frontal eye fields, and inferior parietal lobule during executive function (all positive posterior probabilities <0.1). Individuals with OCD also showed stronger activation in regions of the default mode network during executive function relative to control participants. We found little evidence for differential activation during executive function in task-positive regions related to disease onset, severity, and medication status. Conclusions: In the first mega-analysis of fMRI studies of executive function in OCD, we found strong evidence of weaker frontoparietal activation during executive function tasks. Our findings also suggest a failure of default mode network regions to appropriately disengage during task performance in OCD.
Executive Function in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium / Dzinalija, N.; Veer, I. M.; Simpson, H. B.; Ivanov, I.; Balachander, S.; Benedetti, F.; Calesella, F.; Fitzsimmons, S. M. D. D.; Grutzmann, R.; Hagen, K.; Hansen, B.; Heinzel, S.; Huijser, C.; Ipser, J.; Jaspers-Fayer, F.; De Joode, N. T.; Kathmann, N.; Kim, M.; Kwon, J. S.; Liu, W.; Lochner, C.; Martinez-Zalacain, I.; Menchon, J. M.; Narayanaswamy, J. C.; Olivier, I. S.; Postma, T. S.; Reddy, Y. C. J.; Soriano-Mas, C.; Stewart, S. E.; Thomopoulos, S. I.; Thorsen, A. L.; Vai, B.; Veltman, D. J.; Venkatasubramanian, G.; Voon, V.; Waller, L.; Van Der Werf, Y. D.; Zhao, Y. -J.; Stein, D. J.; Thompson, P. M.; Van Den Heuvel, O. A.; Vriend, C.; Alonso, P.; Best, J. R.; Bravi, B.; Choi, S.; Fortaner-Uya, L.; Kvale, G.; Ousdal, O. T.; Segalas, C.. - In: BIOLOGICAL PSYCHIATRY. - ISSN 2451-9022. - (2026). [Epub ahead of print] [10.1016/j.bpsc.2026.02.007]
Executive Function in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium
Benedetti F.;Calesella F.;Bravi B.;
2026-01-01
Abstract
Background: Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during executive function, we conducted a mega-analysis in the ENIGMA-OCD consortium pooling individual participant data from 475 individuals with OCD and 345 healthy control participants across 15 functional magnetic resonance imaging (fMRI) tasks collected worldwide. Methods: Individual participant data were uniformly processed using HALFpipe to construct voxelwise statistical images of executive processing and task load contrasts. Parameter estimates extracted from regions of interest were entered into multilevel Bayesian models to examine regional and whole-brain effects of diagnosis and, within OCD, the influence of medication status, symptom severity, and age of onset on task activation. Results: We observed a robust task activation pattern across individuals with OCD and control participants in executive processing regions across tasks. Relative to control participants, individuals with OCD showed moderate to very strong evidence of weaker activation of the dorsolateral prefrontal cortex, precuneus, frontal eye fields, and inferior parietal lobule during executive function (all positive posterior probabilities <0.1). Individuals with OCD also showed stronger activation in regions of the default mode network during executive function relative to control participants. We found little evidence for differential activation during executive function in task-positive regions related to disease onset, severity, and medication status. Conclusions: In the first mega-analysis of fMRI studies of executive function in OCD, we found strong evidence of weaker frontoparietal activation during executive function tasks. Our findings also suggest a failure of default mode network regions to appropriately disengage during task performance in OCD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
