A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to α-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to α-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II. Copyright © 2002 S. Karger AG, Basel.
Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy / Perego, L.; Previtali, S. C.; Nemni, R.; Longhi, R.; Carandente, O.; Saibene, A.; Sciolla, R.; Villa, A.; Gai, P.; Panzeri, C.; Dell'Antonio, G.; Quattrini, A.; Folli, F.. - In: EUROPEAN NEUROLOGY. - ISSN 0014-3022. - 47:4(2002), pp. 196-200. [10.1159/000057898]
Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy
Previtali S. C.;
2002-01-01
Abstract
A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to α-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to α-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II. Copyright © 2002 S. Karger AG, Basel.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
