IRIS
6 Brevetti
 Distribuzione geografica
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Continente #
EU - Europa 3.477
AS - Asia 3.286
NA - Nord America 2.055
SA - Sud America 828
AF - Africa 67
OC - Oceania 1
Totale 9.714
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Nazione #
RU - Federazione Russa 1.991
US - Stati Uniti d'America 1.954
SG - Singapore 1.305
CN - Cina 1.036
BR - Brasile 670
SE - Svezia 629
HK - Hong Kong 387
VN - Vietnam 304
IT - Italia 229
FR - Francia 185
DE - Germania 158
FI - Finlandia 108
IN - India 79
GB - Regno Unito 57
AR - Argentina 56
CA - Canada 51
ZA - Sudafrica 34
EC - Ecuador 30
MX - Messico 30
BD - Bangladesh 28
CO - Colombia 26
PL - Polonia 26
ID - Indonesia 24
IQ - Iraq 23
NL - Olanda 21
ES - Italia 13
PY - Paraguay 13
TR - Turchia 12
UA - Ucraina 12
AT - Austria 11
CL - Cile 10
VE - Venezuela 10
IR - Iran 9
MA - Marocco 9
PK - Pakistan 9
RO - Romania 9
JP - Giappone 8
AE - Emirati Arabi Uniti 7
KE - Kenya 6
KZ - Kazakistan 6
SA - Arabia Saudita 6
TN - Tunisia 6
UY - Uruguay 6
JO - Giordania 5
MY - Malesia 5
OM - Oman 5
AZ - Azerbaigian 4
CH - Svizzera 4
EG - Egitto 4
IE - Irlanda 4
IL - Israele 4
JM - Giamaica 4
PA - Panama 4
PE - Perù 4
UZ - Uzbekistan 4
AL - Albania 3
BO - Bolivia 3
CZ - Repubblica Ceca 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
RS - Serbia 3
AM - Armenia 2
BH - Bahrain 2
BY - Bielorussia 2
DZ - Algeria 2
GT - Guatemala 2
LT - Lituania 2
NP - Nepal 2
PH - Filippine 2
TW - Taiwan 2
BE - Belgio 1
BG - Bulgaria 1
CG - Congo 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
EE - Estonia 1
HN - Honduras 1
HR - Croazia 1
KN - Saint Kitts e Nevis 1
LB - Libano 1
MK - Macedonia 1
NZ - Nuova Zelanda 1
PR - Porto Rico 1
PT - Portogallo 1
QA - Qatar 1
SI - Slovenia 1
SN - Senegal 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
TL - Timor Orientale 1
TT - Trinidad e Tobago 1
VG - Isole Vergini Britanniche 1
Totale 9.714
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Città #
Dallas 548
Singapore 428
Moscow 395
Hong Kong 382
Shanghai 243
Ashburn 241
Hefei 174
Beijing 152
San Jose 149
Lauterbourg 148
Lawrence 136
Princeton 136
Ho Chi Minh City 107
Helsinki 83
New York 65
Hanoi 62
São Paulo 57
Milan 51
Los Angeles 50
Orem 50
Munich 34
Washington 27
Turku 24
Boardman 23
Bologna 23
Pune 23
Ancona 22
Warsaw 22
Guangzhou 20
Chennai 19
Johannesburg 19
Da Nang 18
Denver 18
Montreal 18
Nuremberg 18
Rio de Janeiro 18
Rome 18
Stockholm 16
Brasília 15
Brooklyn 15
Curitiba 15
Poplar 15
Toronto 14
Guarulhos 13
Haiphong 13
Atlanta 12
Baghdad 12
Guayaquil 12
Hải Dương 12
Mexico City 12
Amsterdam 10
Dhaka 10
Frankfurt am Main 10
London 10
Manchester 10
Perugia 10
Quito 10
Santa Clara 10
Shenzhen 10
Campinas 9
Houston 9
Cape Town 8
Chicago 8
New Delhi 8
Porto Alegre 8
Tokyo 8
Turin 8
Bogotá 7
Buenos Aires 7
Hangzhou 7
Nova Iguaçu 7
Phoenix 7
Tianjin 7
Falkenstein 6
Nairobi 6
Piracicaba 6
Salvador 6
Santo André 6
São Bernardo do Campo 6
Thái Bình 6
Thái Nguyên 6
Asunción 5
Boston 5
Charlotte 5
Fortaleza 5
Limeira 5
Manaus 5
Montevideo 5
San Francisco 5
Santiago de Cali 5
Tehran 5
Amman 4
Ankara 4
Baku 4
Belo Horizonte 4
Betim 4
Bloomington 4
Canoas 4
Caracas 4
Ciudad del Este 4
Totale 4.529
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Nome #
System for physical activity, and related method 237
[Severe aortic stenosis successfully treated with percutaneous aortic valve implantation] 153
Ablation catheter with flexible tip and methods of making the same 125
2) HERV-H per l'uso come marcatore molecolare del Disturbo dello Spettro Autistico e relativo metodo diagnostico in vitro, kit diagnostico e usi medici (2012).GAUDI S F 116
Permanent Epigenetic Gene Silencing 108
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 107
INCREASE OF MYELOID MICROVESICLES IN THE CEREBROSPINAL FLUID AS BIOMARKER OF MICROGLIA/MACROPHAGE ACTIVATION IN NEUROLOGICAL DISORDERS 104
COMPOSITIONS AND METHODS FOR EPIGENETIC REGULATION OF HBV GENE EXPRESSION 100
GENE SILENCING 100
Sistema per svolgere attività fisica, e relativo procedimento 97
Dispositivo di cannulazione vascolare 94
Treatment and Prevention of Cancer with HMGB1 Antagonists 94
HMGB1 inhibitors and antagonista for the inhibition of atherosclerosis pathogenesis and development 93
RECOMBINANT LENTIVIRAL VECTOR FOR STEM CELL-BASED GENE THERAPY OF SICKLE CELL DISORDER 93
ACETYLATED HMGB1 PROTEIN 93
Use of HMGB2 and HMGB3 proteins for medical applications 91
VIRAL VECTOR COMBINING GENE THERAPY AND GENOME EDITING APPROACHES FOR GENE THERAPY OF GENETIC DISORDERS 86
Adjuvant incorporation in immunoanotherapeutics 86
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 83
HMGB1 protein inhibitors for the regulation of smooth muscle cells and endothelial cells proliferation 81
Novel biomarkers 77
VECTOR PRODUCTION 76
Methods and compositions for targeted integration 75
Agents regulating vascular permeability 72
Formulations to administer SUMO2/3 70
PROCEDIMENTO E SISTEMA PER LA RILEVAZIONE DI RISPOSTE BINARIE TRAMITE ANALISI DEL DIAMETRO PUPILLARE DI UN SOGGETTO 69
Spinginodo 67
Inhibitors of hepatitis B virus 66
Bottone anastomotico frammentabile 65
Anti-HCV monoclonal antibody as a medicament for the therapeutic treatment and prevention of HCV infections 65
Structure and function of the salicyclic acid binding sites on human hmgb1 and methods of use thereof for the rational design of both salicyclic acid derivatives and other agents that alter animal and plant hmgbs activities 64
MEZZO PER VEDERE UNA VALVOLA CARDIACA IN FASE INTRAOPERATORIA 63
Method for the preparation of new oligoclonal antibodies 62
Tricuspid valve repair using tension 62
Use of IL-7 and IL-15 for the genetic modification of memory T lymphocytes 62
Vaccine nanotechnology 62
Collagen Scaffold in nervous system regeneration 60
Delivery tool for implantation of spool assembly coupled to a helical anchor 60
Human monoclonal recombinant antibody against NS3 HCV protein and methods therefor 59
Anti-idiotype monoclonal antibody directed against anti-TNF antibodies 59
Hmgb1 variants and uses thereof 59
Cyclic inhibitors of hepatitis B virus 59
Tricyclic inhibitors of hepatitis B virus 59
Cytokine conjugates (IL-12 –peptide conjugates) 58
Suturatrice meccanica circolare 58
Immunonanotherapeutics that provide IgG humoral response without T-cell antigen 58
INFLUENZA VIRUS AND TYPE 1 DIABETES 58
DISPOSITIVO PER USO IN EMODINAMICA 58
Phage Display Technology 57
Anti-idiotype monoclonal antibodies as mimotopes of the HIV gp120 antigen 57
Cromogranina A per uso come reagente in un metodo diagnostico o prognostico 57
“Non-invasive ventilation mask and use thereof” 57
Methods for treating cardiac reperfusion injury 57
Anti-urokinase monoclonal antibody, matrix bearing it, test method, biochemical test kits which use it. 56
Receptor-antibody sandwich assay. 56
Control for a Remote Navigation System 56
Magnetically Guided Catheter With Flexible Tip 56
PROTESI ANULARE PER VALVOLA MITRALE 56
Suturatrice meccanica circolare 55
Monoclonal antibodies as a medicament for the therapeutic and/or prophylactic treatment of swine-origin influenza A (H1N1) virus (S-OIV) infections 55
Monoclonal antibodies against the TNF type-I receptor, process for their production and use thereofAnticorpi monoclonali anti-recettore di tipo 1 del TNF alfa, procedimento per la loro produzione e loro uso 55
System and methods for locating and ablating arrhythomogenic tissues 55
Nicotine immunonanotherapeutics 55
RETAINING MECHANISMS FOR PROSTHETIC VALVES 55
Real heart case simulator 55
Monoclonal antibodies having homosubtype cross-neutralization properties against influenza A viruses subtype H1 54
Immobilized oligopeptides 54
Method and apparatus for tricuspid valve repair using tension 54
Suturatrice automatica per borsa di tabacco 54
Dispositivo per la chirurgia endoscopica transanale 54
Method of treating cardiac arrhythmias 54
Irrigated Catheter with Improved fluid flow 54
CARDIAC TISSUE CINCHING 54
FOSSA OVALIS PENETRATION APPARATUS 54
Human Monoclonal Antibody Fab Fragments directed against HCV E2 glycoprotein and endowed with neutralizing activity 53
System and Network for Remote Medical Procedures 53
METHOD AND SYSTEM FOR DETECTING VOLUNTARY BINARY RESPONSES BY ANALYZING THE PUPIL DIAMETER OF A SUBJECT 53
Targeting of antigen presenting cells with immunonanotherapeutics 53
FOSSA OVALIS PENETRATION USING PROBING ELEMENTS 53
SULFONAMIDES USEFUL IN THE PREVENTION OF DIABETES 52
Réparation de valve tricuspide à l'aide d'une tension 52
Anti-HCV monoclonal antibody as a medicament for the therapeutic treatment and prevention of HCV infections 52
Liver gene expression associated with the inhibition of HBV replication or transcription 52
Multi-Electrode Irrigated Balloon Catheter 52
PERCUTANEOUS TETHER LOCKING 52
INHIBITORS OF CXCR1/2 AS ADJUVANTS IN THE TRANSPLANT OF PANCREATIC ISLETS 51
Dispositivo anastomotico ad anelli 51
Dispositivo anastomotico ad anelli 51
Use of common gamma-chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes 51
STK4 inhibitors for treatment of hematological malignancies 51
IMPLANTATION OF REPAIR CHORDS IN THE HEART 51
Non linear peptides hydropathically complementary to know amino acid sequences, process for the production and used thereof 50
Combination product (Use of IDO inhibitors in cancer therapy with targeted interferon gamma) 50
Dispositivo ad anelli frammentabili 50
SUMO and uses thereof 50
Strumento automatico per suture a borsa di tabacco 49
Solid-phase receptor assay for antibiotics of the vancomycin class. 49
Modified cytokines for therapeutic use 49
Novel Targets in Multiple Myeloma and Other Disorders 49
ADJUSTABLE REPAIR CHORDS AND SPOOL MECHANISM THEREFOR 49
Totale 6.687
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211 0 0 0 0 0 0 0 0 0 0 1 0
2021/2022142 4 0 0 84 4 4 3 9 10 12 6 6
2022/2023933 299 260 109 3 1 113 8 36 58 11 15 20
2023/2024473 40 11 132 32 23 46 12 29 0 31 12 105
2024/20252.186 259 38 61 86 33 166 320 158 351 224 252 238
2025/20266.031 480 602 500 898 474 171 488 449 1.730 239 0 0
Totale 9.792