COVID-19 survivors are at increased risk of persistent psychopathology after the infection. Despite long-term sequelae are an increasing concern, long-term neuropsychiatric consequences remain largely unclear. This cohort study aimed at investigating the psychopathological impact of COVID-19 in Italy one year after infection, outlining the trajectory of symptomatology at one, six-, and twelve-months follow-up. We evaluated 402, 216, and 192 COVID-19 survivors respectively at one, six, and 12 months. A subgroup of 95 patients was evaluated longitudinally both at one, six, and 12 months. Validated self-report questionnaires were administered to assess depression, fatigue, anxiety, and post-traumatic distress. Socio-demographics and setting of care information were gathered for each participant. At six and twelve months, respectively 94 (44%) and 86 (45%) patients self-rated in the clinical range in at least one psychopathological dimension. Pathological fatigue at twelve months was detected in 63 patients (33%). Considering the longitudinal cohort an interaction effect of sex and time was observed for depression (F = 8.63, p < 0.001) and anxiety (F = 5.42, p = 0.005) with males showing a significant increasing trend of symptoms, whereas an opposite course was observed in females. High prevalence of psychiatric sequelae six and 12 months after COVID-19 was reported for the first time. These findings confirm the need to provide integrated multidisciplinary services to properly address long-lasting mental health sequelae of COVID-19 and to treat them with the aim of reducing the disease burden and related years of life lived with disability.

One-year mental health outcomes in a cohort of COVID-19 survivors / Mazza, M. G.; Palladini, M.; De Lorenzo, R.; Bravi, B.; Poletti, S.; Furlan, R.; Ciceri, F.; Vai, B.; Bollettini, I.; Melloni, E. M. T.; Mazza, E. B.; Aggio, V.; Calesella, F.; Paolini, M.; Caselani, E.; Colombo, F.; D'Orsi, G.; Di Pasquasio, C.; Fiore, P.; Calvisi, S.; Canti, V.; Castellani, J.; Cilla, M.; Cinel, E.; Damanti, S.; Ferrante, M.; Martinenghi, S.; Santini, C.; Vitali, G.; Rovere-Querini, P.; Benedetti, F.. - In: JOURNAL OF PSYCHIATRIC RESEARCH. - ISSN 0022-3956. - 145:(2022), pp. 118-124. [Epub ahead of print] [10.1016/j.jpsychires.2021.11.031]

One-year mental health outcomes in a cohort of COVID-19 survivors

Mazza M. G.;Palladini M.;De Lorenzo R.;Bravi B.;Furlan R.;Ciceri F.;Bollettini I.;Melloni E. M. T.;Mazza E. B.;Calesella F.;Paolini M.;Colombo F.;Fiore P.;Castellani J.;Cilla M.;Cinel E.;Ferrante M.;Santini C.;Rovere-Querini P.;Benedetti F.
2022-01-01

Abstract

COVID-19 survivors are at increased risk of persistent psychopathology after the infection. Despite long-term sequelae are an increasing concern, long-term neuropsychiatric consequences remain largely unclear. This cohort study aimed at investigating the psychopathological impact of COVID-19 in Italy one year after infection, outlining the trajectory of symptomatology at one, six-, and twelve-months follow-up. We evaluated 402, 216, and 192 COVID-19 survivors respectively at one, six, and 12 months. A subgroup of 95 patients was evaluated longitudinally both at one, six, and 12 months. Validated self-report questionnaires were administered to assess depression, fatigue, anxiety, and post-traumatic distress. Socio-demographics and setting of care information were gathered for each participant. At six and twelve months, respectively 94 (44%) and 86 (45%) patients self-rated in the clinical range in at least one psychopathological dimension. Pathological fatigue at twelve months was detected in 63 patients (33%). Considering the longitudinal cohort an interaction effect of sex and time was observed for depression (F = 8.63, p < 0.001) and anxiety (F = 5.42, p = 0.005) with males showing a significant increasing trend of symptoms, whereas an opposite course was observed in females. High prevalence of psychiatric sequelae six and 12 months after COVID-19 was reported for the first time. These findings confirm the need to provide integrated multidisciplinary services to properly address long-lasting mental health sequelae of COVID-19 and to treat them with the aim of reducing the disease burden and related years of life lived with disability.
2022
Anxiety
COVID-19
Depression
Fatigue
Mental health
SARS-CoV-2
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11768/121435
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