IRIS
NALDINI, LUIGI
 Distribuzione geografica
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Continente #
EU - Europa 1.880
NA - Nord America 1.416
AS - Asia 736
AF - Africa 15
OC - Oceania 11
SA - Sud America 4
Totale 4.062
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Nazione #
US - Stati Uniti d'America 1.405
SE - Svezia 1.022
SG - Singapore 323
RU - Federazione Russa 314
IT - Italia 311
CN - Cina 307
FI - Finlandia 57
DE - Germania 42
IN - India 41
IE - Irlanda 36
GB - Regno Unito 31
NL - Olanda 21
JP - Giappone 17
CA - Canada 11
FR - Francia 11
AU - Australia 10
TW - Taiwan 8
CH - Svizzera 7
ES - Italia 7
TR - Turchia 6
AT - Austria 5
ET - Etiopia 5
HK - Hong Kong 5
KR - Corea 5
BE - Belgio 4
IR - Iran 4
VN - Vietnam 4
BG - Bulgaria 3
BR - Brasile 3
DZ - Algeria 3
IL - Israele 3
MA - Marocco 3
PL - Polonia 3
EG - Egitto 2
ID - Indonesia 2
IQ - Iraq 2
MK - Macedonia 2
NG - Nigeria 2
PS - Palestinian Territory 2
AM - Armenia 1
AR - Argentina 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LI - Liechtenstein 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PK - Pakistan 1
PT - Portogallo 1
SA - Arabia Saudita 1
TH - Thailandia 1
UA - Ucraina 1
Totale 4.062
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Città #
Princeton 316
Lawrence 315
Singapore 206
Ashburn 178
Shanghai 152
Moscow 140
New York 103
Milan 100
Boardman 63
Helsinki 55
Dublin 34
Washington 34
Pune 28
Guangzhou 24
Los Angeles 24
Dallas 21
Seattle 14
Jiaxing 11
Monza 11
Beijing 10
Cambridge 10
Rome 10
London 9
Borås 7
Shenzhen 6
St Petersburg 6
Xi'an 6
Aksum 5
Barcelona 5
Bari 5
Brisbane 5
Stockholm 5
Tokyo 5
Vienna 5
Brooklyn 4
Chevy Chase 4
Delhi 4
Genoa 4
Hamburg 4
Naaldwijk 4
Parma 4
Philadelphia 4
Pisa 4
San Francisco 4
Toronto 4
Verona 4
Villejuif 4
Algiers 3
Ancona 3
Ankara 3
Bergamo 3
Berlin 3
Cinisello Balsamo 3
Florence 3
Gijang-gun 3
Gravina di Catania 3
Hanover 3
Istanbul 3
Kassel 3
Las Vegas 3
Loughton 3
Moorestown 3
Munich 3
Nantou City 3
Naples 3
Paris 3
Park City 3
Santa Clara 3
Schaarbeek 3
Schafisheim 3
Trento 3
Zhengzhou 3
Amsterdam 2
Arezzo 2
Athlone 2
Aurora 2
Barnet 2
Belluno 2
Bengaluru 2
Berkeley 2
Bethesda 2
Bologna 2
Camden 2
Carugate 2
Cherry Hill 2
Chicago 2
Clifton 2
Clusone 2
Como 2
Cortona 2
Council Bluffs 2
Dalian 2
Davis 2
Dayton 2
Daytona Beach 2
Duhok 2
Düsseldorf 2
Farmington 2
Frankfurt am Main 2
Fremont 2
Totale 2.111
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 218
Genotoxic effects of base and prime editing in human hematopoietic stem cells 48
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 48
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 46
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases 44
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 37
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 35
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 34
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 32
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 32
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 29
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 28
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 28
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 27
Site-specific integration and tailoring of cassette design for sustainable gene transfer 27
An unbiased genome-wide analysis of zinc-finger nuclease specificity 26
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 25
Gene therapy returns to centre stage 24
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia 24
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates 24
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 23
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 23
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia 23
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 22
Tie2-expressing Monocytes: Regulation by Hpoxia and angioprotein. 22
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 22
A Comeback for Gene Therapy 22
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 22
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 21
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 21
Gene therapy for a mucopolysaccharidosis type I murine model with lentiviral-IDUA vector 21
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 21
Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice 21
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 21
Adopt a moratorium on heritable genome editing 21
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 21
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 21
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy 20
Liver-directed lentiviral gene therapy in a dog model of hemophilia B 20
From TCR Gene Transfer to TCR Gene Editing of Central Memory T Lymphocytes for Immunotherapy of Leukemia 20
TCR gene editing results in effective immunotherapy of leukaemia without the development of GvHD 20
WFH State-of-the-art paper 2020: In vivo lentiviral vector gene therapy for haemophilia 20
Retrieval of vector integration sites from cell-free DNA 20
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 20
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 20
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 19
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 19
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 19
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 19
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 19
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 19
SCATTER FACTOR AND HEPATOCYTE GROWTH-FACTOR ARE INDISTINGUISHABLE LIGANDS FOR THE MET RECEPTOR 19
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 19
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. 19
Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo 19
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 19
Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy 19
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 19
Targeted genome editing in human repopulating haematopoietic stem cells 18
Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice 18
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 18
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 18
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery 18
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 18
Genomic instability in induced stem cells 18
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 18
Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency 17
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 17
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 17
T Cell Receptor Gene Transfer into Early Differentiated Lymphocytes by Lentiviral Vectors for Safe and Effective Adoptive Immune Therapy of Leukemia 17
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 17
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 17
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 17
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 17
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 16
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 16
Shedding of clinical-grade lentiviral vectors is not detected in a gene therapy setting 16
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 16
In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases 16
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 16
Hematopoietic Stem Cell Gene Transfer in a Tumor-Prone Mouse Model Uncovers Low Genotoxicity of Lentiviral Vector Integration 16
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice 16
miR-511-3p modulates genetic programs of tumor-associated macrophages 16
IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment 16
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 16
Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes 16
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 16
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 15
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer 15
MULTIPLY ATTENUATED LENTIVIRAL VECTOR ACHIEVES EFFICIENT GENE DELIVERY IN VIVO 15
In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors 15
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice 15
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 15
Targeting Integration to Selected Genomic Loci and In Situ Tailoring of Cassette Design Allows Robust Transgene Expression without Perturbing Endogenous Transcription 15
Mouse Models To Assess the Risk of Vector Insertional Mutagenesis upon Systemic Delivery 15
Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells 15
LENTIVIRAL VECTOR TRANSDUCED CD34+CELLS FOR THE TREATMENT OF WISKOTT-ALDRICH SYNDROME 15
MNK2 governs the macrophage antiinflammatory phenotype 15
Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation 14
Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. 14
Totale 2.292
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Categoria #
all - tutte 79.951
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 79.951
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202015 0 0 0 0 2 1 0 0 1 11 0 0
2020/202146 0 10 0 2 4 19 6 0 3 2 0 0
2021/2022207 1 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/20241.161 42 62 138 132 116 218 43 89 10 64 73 174
2024/2025968 548 78 68 165 109 0 0 0 0 0 0 0
Totale 4.376