IRIS
NALDINI, LUIGI
 Distribuzione geografica
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Continente #
EU - Europa 1.444
NA - Nord America 1.268
AS - Asia 152
AF - Africa 10
OC - Oceania 6
SA - Sud America 4
Totale 2.884
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Nazione #
US - Stati Uniti d'America 1.260
SE - Svezia 1.018
IT - Italia 223
CN - Cina 70
FI - Finlandia 54
IN - India 36
IE - Irlanda 35
DE - Germania 30
GB - Regno Unito 23
RU - Federazione Russa 18
JP - Giappone 17
NL - Olanda 9
CA - Canada 8
ES - Italia 7
FR - Francia 7
CH - Svizzera 6
SG - Singapore 6
TW - Taiwan 6
AU - Australia 5
ET - Etiopia 5
HK - Hong Kong 5
BE - Belgio 4
IR - Iran 4
KR - Corea 4
AT - Austria 3
BR - Brasile 3
DZ - Algeria 3
BG - Bulgaria 2
ID - Indonesia 2
MK - Macedonia 2
PL - Polonia 2
AR - Argentina 1
EG - Egitto 1
NG - Nigeria 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
TR - Turchia 1
VN - Vietnam 1
Totale 2.884
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Città #
Princeton 316
Lawrence 315
Ashburn 177
New York 101
Milan 86
Shanghai 64
Helsinki 54
Washington 34
Dublin 33
Pune 28
Los Angeles 17
Seattle 13
Cambridge 10
Rome 8
Borås 7
London 6
St Petersburg 6
Aksum 5
Barcelona 5
Monza 5
Tokyo 5
Brooklyn 4
Chevy Chase 4
Delhi 4
Genoa 4
Moscow 4
Naaldwijk 4
Philadelphia 4
Toronto 4
Verona 4
Villejuif 4
Algiers 3
Ancona 3
Bari 3
Bergamo 3
Brisbane 3
Cinisello Balsamo 3
Florence 3
Gijang-gun 3
Gravina di Catania 3
Hanover 3
Loughton 3
Moorestown 3
Nantou City 3
Naples 3
Park City 3
San Francisco 3
Schaarbeek 3
Schafisheim 3
Vienna 3
Zhengzhou 3
Arezzo 2
Athlone 2
Aurora 2
Belluno 2
Berkeley 2
Berlin 2
Bethesda 2
Boardman 2
Bologna 2
Camden 2
Carugate 2
Cherry Hill 2
Chicago 2
Clusone 2
Como 2
Cortona 2
Council Bluffs 2
Davis 2
Dayton 2
Düsseldorf 2
Farmington 2
Fremont 2
Hong Kong 2
Hyderabad 2
Kingston upon Thames 2
Kyoto 2
Langhirano 2
Las Vegas 2
Madrid 2
Mestre 2
Mountain View 2
Munich 2
Muttenz 2
Nerviano 2
New Castle 2
Newtown 2
Novara 2
Palo Alto 2
Paris 2
Parma 2
Perugia 2
Plovdiv 2
Riolo Terme 2
Roncaro 2
Roslindale 2
Ruislip 2
Salerno 2
Schiphol 2
Strambino 2
Totale 1.493
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 170
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 44
Genotoxic effects of base and prime editing in human hematopoietic stem cells 43
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 29
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 28
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 26
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 26
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 25
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 23
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 23
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 22
Site-specific integration and tailoring of cassette design for sustainable gene transfer 22
An unbiased genome-wide analysis of zinc-finger nuclease specificity 21
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia 21
Gene therapy returns to centre stage 20
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 20
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia 20
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 20
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates 19
Tie2-expressing Monocytes: Regulation by Hpoxia and angioprotein. 18
A Comeback for Gene Therapy 18
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 17
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 17
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 16
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 16
Gene therapy for a mucopolysaccharidosis type I murine model with lentiviral-IDUA vector 16
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 16
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 16
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 16
From TCR Gene Transfer to TCR Gene Editing of Central Memory T Lymphocytes for Immunotherapy of Leukemia 16
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 16
Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo 16
TCR gene editing results in effective immunotherapy of leukaemia without the development of GvHD 16
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 16
Adopt a moratorium on heritable genome editing 16
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 16
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 16
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 15
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 15
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 15
Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice 15
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. 15
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 15
WFH State-of-the-art paper 2020: In vivo lentiviral vector gene therapy for haemophilia 15
Genomic instability in induced stem cells 15
Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy 15
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 15
Retrieval of vector integration sites from cell-free DNA 15
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 15
Targeted genome editing in human repopulating haematopoietic stem cells 14
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 14
Liver-directed lentiviral gene therapy in a dog model of hemophilia B 14
Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice 14
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 14
T Cell Receptor Gene Transfer into Early Differentiated Lymphocytes by Lentiviral Vectors for Safe and Effective Adoptive Immune Therapy of Leukemia 14
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery 14
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 13
Shedding of clinical-grade lentiviral vectors is not detected in a gene therapy setting 13
Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency 13
In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors 13
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 13
Targeting Integration to Selected Genomic Loci and In Situ Tailoring of Cassette Design Allows Robust Transgene Expression without Perturbing Endogenous Transcription 13
Mouse Models To Assess the Risk of Vector Insertional Mutagenesis upon Systemic Delivery 13
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 13
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 13
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 13
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 12
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 12
MULTIPLY ATTENUATED LENTIVIRAL VECTOR ACHIEVES EFFICIENT GENE DELIVERY IN VIVO 12
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 12
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 12
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 12
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 12
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 12
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 12
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 12
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 12
Hematopoietic Stem Cell Gene Transfer in a Tumor-Prone Mouse Model Uncovers Low Genotoxicity of Lentiviral Vector Integration 12
Modulation of immune responses in lentiviral vector-mediated gene transfer 12
miR-511-3p modulates genetic programs of tumor-associated macrophages 12
IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment 12
MNK2 governs the macrophage antiinflammatory phenotype 12
Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes 12
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 11
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 11
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 11
IN VIVO GENE DELIVERY AND STABLE TRANSDUCTION OF NONDIVIDING CELLS BY A LENTIVIRAL VECTOR 11
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy 11
Ex vivo gene transfer and correction for cell-based therapies 11
FcR gamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis 11
Targeted gene therapy and cell reprogramming in Fanconi anemia 11
SCATTER FACTOR AND HEPATOCYTE GROWTH-FACTOR ARE INDISTINGUISHABLE LIGANDS FOR THE MET RECEPTOR 11
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 11
In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases 11
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 11
Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells 11
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice 11
LENTIVIRAL VECTOR TRANSDUCED CD34+CELLS FOR THE TREATMENT OF WISKOTT-ALDRICH SYNDROME 11
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 11
Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings 11
Totale 1.715
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Categoria #
all - tutte 52.519
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.519
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191 0 0 0 0 0 0 0 0 0 0 1 0
2019/202035 17 0 0 3 2 1 0 0 1 11 0 0
2020/202146 0 10 0 2 4 19 6 0 3 2 0 0
2021/2022207 1 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/2024913 42 62 138 132 116 218 43 89 10 63 0 0
Totale 3.160