IRIS
NALDINI, LUIGI
 Distribuzione geografica
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Continente #
EU - Europa 9.266
NA - Nord America 8.824
AS - Asia 7.897
SA - Sud America 1.976
Continente sconosciuto - Info sul continente non disponibili 460
AF - Africa 216
OC - Oceania 21
Totale 28.660
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Nazione #
US - Stati Uniti d'America 8.210
RU - Federazione Russa 4.889
SG - Singapore 2.815
CN - Cina 2.487
IT - Italia 1.614
BR - Brasile 1.608
SE - Svezia 1.060
HK - Hong Kong 988
VN - Vietnam 753
FR - Francia 406
DE - Germania 367
CA - Canada 289
GB - Regno Unito 239
IN - India 181
BD - Bangladesh 158
AR - Argentina 134
FI - Finlandia 107
MX - Messico 107
AT - Austria 105
NL - Olanda 100
PL - Polonia 81
ID - Indonesia 79
ZA - Sudafrica 77
JP - Giappone 76
EC - Ecuador 65
ES - Italia 63
TR - Turchia 58
CO - Colombia 49
IQ - Iraq 48
IE - Irlanda 46
CR - Costa Rica 43
VE - Venezuela 39
UA - Ucraina 37
JM - Giamaica 35
MA - Marocco 33
CH - Svizzera 27
PK - Pakistan 27
PY - Paraguay 26
CL - Cile 25
DZ - Algeria 25
LT - Lituania 22
MY - Malesia 20
SA - Arabia Saudita 20
TT - Trinidad e Tobago 20
UZ - Uzbekistan 20
SV - El Salvador 19
BE - Belgio 18
IL - Israele 18
AU - Australia 17
HN - Honduras 17
JO - Giordania 16
KE - Kenya 16
AE - Emirati Arabi Uniti 15
EG - Egitto 14
PH - Filippine 14
TN - Tunisia 14
UY - Uruguay 14
GT - Guatemala 13
NP - Nepal 13
PR - Porto Rico 13
RO - Romania 12
DO - Repubblica Dominicana 11
ET - Etiopia 11
GR - Grecia 11
KR - Corea 11
NI - Nicaragua 10
TW - Taiwan 10
AL - Albania 9
CW - ???statistics.table.value.countryCode.CW??? 9
IR - Iran 9
PE - Perù 9
TH - Thailandia 8
AZ - Azerbaigian 7
BB - Barbados 7
BG - Bulgaria 7
CZ - Repubblica Ceca 7
GP - Guadalupe 7
CI - Costa d'Avorio 6
KZ - Kazakistan 6
LB - Libano 6
PS - Palestinian Territory 6
BO - Bolivia 4
BY - Bielorussia 4
CU - Cuba 4
DK - Danimarca 4
MD - Moldavia 4
MO - Macao, regione amministrativa speciale della Cina 4
NG - Nigeria 4
PA - Panama 4
PT - Portogallo 4
AM - Armenia 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
BS - Bahamas 3
CY - Cipro 3
GD - Grenada 3
GE - Georgia 3
HU - Ungheria 3
KG - Kirghizistan 3
LV - Lettonia 3
Totale 28.154
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Città #
Ashburn 1.281
Singapore 1.222
Moscow 1.081
Hong Kong 973
San Jose 973
Dallas 796
Shanghai 458
Milan 457
Council Bluffs 413
Hefei 367
Princeton 318
Lauterbourg 317
Lawrence 315
New York 281
Beijing 279
Ho Chi Minh City 256
Los Angeles 189
Santa Clara 169
Hanoi 155
São Paulo 154
Phoenix 128
Boardman 101
Nuremberg 101
Miano 86
Rome 85
Orem 78
Munich 73
Helsinki 72
Montreal 67
Rio de Janeiro 65
Chicago 57
Warsaw 57
Washington 57
Brooklyn 56
London 55
Atlanta 54
The Dalles 51
Vienna 51
Tokyo 50
Denver 49
Johannesburg 49
Guangzhou 45
Houston 44
Cesano Boscone 43
Chennai 43
Haiphong 43
Boston 39
Dublin 39
Frankfurt am Main 39
Stockholm 38
Toronto 38
Seattle 36
Da Nang 35
Mexico City 35
Curitiba 34
Brasília 33
Poplar 32
San José 32
Brescia 30
Belo Horizonte 29
Manchester 29
Turin 29
Las Vegas 28
Mumbai 28
Pune 28
Naples 26
North Bergen 26
Tianjin 25
Philadelphia 23
Turku 23
Buffalo 22
Guayaquil 22
Columbus 21
Amsterdam 20
Charlotte 20
Hangzhou 20
Istanbul 20
Kingston 20
Salvador 20
San Francisco 20
Biên Hòa 18
Campinas 18
Guarulhos 18
Monza 18
Quito 18
Tashkent 18
Bologna 17
Hải Dương 17
Shenzhen 17
The Bronx 17
Falkenstein 16
Ankara 15
Baghdad 15
Bogotá 15
New Delhi 15
Porto Alegre 15
Amman 14
Dhaka 14
Florence 14
Genoa 14
Totale 13.396
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 456
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 264
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases 213
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 198
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 198
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 188
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 185
Genotoxic effects of base and prime editing in human hematopoietic stem cells 169
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 167
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 161
Adopt a moratorium on heritable genome editing 158
Long-term lineage commitment in haematopoietic stem cell gene therapy 155
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 155
Genotoxicity concerns for base and prime editors in hematopoietic stem cells 153
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 151
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells 151
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 151
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 149
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 146
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 144
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 141
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells 140
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 136
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 134
GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice 133
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency 133
MNK2 governs the macrophage antiinflammatory phenotype 132
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 132
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 128
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 128
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 126
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 124
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 123
Permanent Epigenetic Gene Silencing 122
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 122
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 122
An unbiased genome-wide analysis of zinc-finger nuclease specificity 122
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 121
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer 119
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 118
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 117
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 116
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 116
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 116
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 116
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 115
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 111
Retrieval of vector integration sites from cell-free DNA 111
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 111
Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates 110
A Comeback for Gene Therapy 110
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 105
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice 105
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 105
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood “resident” monocytes and embryonic macrophages suggests common functions and developmental relationships 105
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 104
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 104
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 103
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 103
VisualZoneR: A computational protocol to identify compartmental zones from single-cell spatial transcriptomics using R 102
A gene mutatioons reinforces genotype-phenotype correlation in metachromatic leukodystrophy 102
Combining Site-Specific Integration and Cassette Design to Achieve Robust Expression Without Impacting Endogenous Gene Expression 102
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 101
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 100
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 99
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 98
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 97
Combining Targeted Integration and Cassette Design for Robust and Benign Transgene Expression without Impacting Endogenous Gene Transcription 96
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 95
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 95
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 94
HEPATOCYTE GROWTH-FACTOR IS A POTENT ANGIOGENIC FACTOR WHICH STIMULATES ENDOTHELIAL-CELL MOTILITY AND GROWTH 94
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 94
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 94
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates 94
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer 93
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 93
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 92
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 92
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 91
IFNalpha by In Vivo-Engineered Macrophages Abates Liver Metastases and Triggers Counter Regulatory Responses Limiting Efficacy 90
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 89
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 88
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 88
TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength 88
Single-cell transcriptomics uncovers cellular and molecular determinants of tissue myeloid cell heterogeneity in homeostasis and cancer 87
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 87
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 87
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 86
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery 86
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector) 86
IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy 85
VECTOR PRODUCTION 85
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. 85
A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice 85
In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation 84
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 84
Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1 84
Methods and compositions for targeted integration 83
IN VIVO GENE DELIVERY AND STABLE TRANSDUCTION OF NONDIVIDING CELLS BY A LENTIVIRAL VECTOR 82
Totale 12.088
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Categoria #
all - tutte 176.368
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 176.368
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022206 0 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/20241.168 42 62 138 132 116 218 43 89 10 64 78 176
2024/20255.089 554 78 68 170 209 396 671 563 818 672 442 448
2025/202616.169 1.126 1.229 1.153 2.256 1.136 504 1.478 1.196 4.439 891 329 432
2026/20273.987 446 985 922 1.634 0 0 0 0 0 0 0 0
Totale 28.660