IRIS
NALDINI, LUIGI
 Distribuzione geografica
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Continente #
EU - Europa 8.601
AS - Asia 7.837
NA - Nord America 6.746
SA - Sud America 1.957
Continente sconosciuto - Info sul continente non disponibili 451
AF - Africa 215
OC - Oceania 21
Totale 25.828
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Nazione #
US - Stati Uniti d'America 6.378
RU - Federazione Russa 4.889
SG - Singapore 2.799
CN - Cina 2.476
BR - Brasile 1.601
SE - Svezia 1.060
IT - Italia 1.014
HK - Hong Kong 981
VN - Vietnam 752
FR - Francia 406
DE - Germania 362
GB - Regno Unito 207
IN - India 179
CA - Canada 168
BD - Bangladesh 157
AR - Argentina 133
FI - Finlandia 107
AT - Austria 105
MX - Messico 105
NL - Olanda 96
PL - Polonia 81
ZA - Sudafrica 77
ID - Indonesia 75
JP - Giappone 71
EC - Ecuador 62
ES - Italia 60
TR - Turchia 54
IQ - Iraq 48
CO - Colombia 46
IE - Irlanda 45
UA - Ucraina 34
VE - Venezuela 34
MA - Marocco 33
PK - Pakistan 26
PY - Paraguay 26
CL - Cile 25
DZ - Algeria 25
LT - Lituania 21
CH - Svizzera 20
UZ - Uzbekistan 20
SA - Arabia Saudita 19
BE - Belgio 18
AU - Australia 17
IL - Israele 17
MY - Malesia 17
CR - Costa Rica 16
JO - Giordania 16
KE - Kenya 16
AE - Emirati Arabi Uniti 14
EG - Egitto 14
PH - Filippine 14
TN - Tunisia 14
UY - Uruguay 14
NP - Nepal 13
DO - Repubblica Dominicana 11
ET - Etiopia 11
GR - Grecia 11
JM - Giamaica 11
KR - Corea 10
TW - Taiwan 10
HN - Honduras 9
IR - Iran 9
PE - Perù 9
AL - Albania 8
TH - Thailandia 8
TT - Trinidad e Tobago 8
AZ - Azerbaigian 7
BG - Bulgaria 7
CZ - Repubblica Ceca 7
BB - Barbados 6
CI - Costa d'Avorio 6
GT - Guatemala 6
KZ - Kazakistan 6
PS - Palestinian Territory 6
SV - El Salvador 6
LB - Libano 5
BO - Bolivia 4
BY - Bielorussia 4
DK - Danimarca 4
MD - Moldavia 4
MO - Macao, regione amministrativa speciale della Cina 4
NG - Nigeria 4
PA - Panama 4
PT - Portogallo 4
RO - Romania 4
AM - Armenia 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
CY - Cipro 3
GE - Georgia 3
HU - Ungheria 3
KG - Kirghizistan 3
LV - Lettonia 3
MK - Macedonia 3
PR - Porto Rico 3
RS - Serbia 3
SN - Senegal 3
SY - Repubblica araba siriana 3
BS - Bahamas 2
DM - Dominica 2
Totale 25.333
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Città #
Singapore 1.216
Moscow 1.081
Hong Kong 966
Ashburn 866
Dallas 784
San Jose 759
Shanghai 457
Council Bluffs 402
Hefei 367
Lauterbourg 317
Princeton 316
Lawrence 315
Beijing 273
New York 270
Ho Chi Minh City 256
Milan 255
Los Angeles 171
Hanoi 154
São Paulo 154
Santa Clara 145
Nuremberg 101
Boardman 100
Orem 77
Munich 73
Helsinki 72
Rio de Janeiro 65
Rome 62
Warsaw 57
Montreal 56
Washington 53
Vienna 51
Phoenix 50
Johannesburg 49
Brooklyn 48
Chicago 48
Tokyo 47
Guangzhou 45
London 44
Cesano Boscone 43
Denver 43
Haiphong 43
The Dalles 42
Chennai 41
Dublin 39
Houston 39
Atlanta 38
Frankfurt am Main 38
Stockholm 38
Da Nang 35
Curitiba 34
Mexico City 34
Brasília 32
Poplar 32
Seattle 32
Boston 30
Belo Horizonte 29
Toronto 29
Brescia 28
Mumbai 28
Pune 28
Tianjin 25
Manchester 23
Turku 23
Guayaquil 22
Turin 22
Columbus 21
Las Vegas 21
Amsterdam 20
Hangzhou 20
Salvador 20
San Francisco 20
Charlotte 19
Biên Hòa 18
Campinas 18
Guarulhos 18
Istanbul 18
Tashkent 18
Buffalo 17
Hải Dương 17
Monza 17
Philadelphia 17
Shenzhen 17
Falkenstein 16
Quito 16
Ankara 15
Baghdad 15
New Delhi 15
Porto Alegre 15
Amman 14
Bogotá 14
Bologna 14
Dhaka 14
Genoa 14
Jiaxing 14
Nairobi 14
Naples 14
Caxias do Sul 13
Montevideo 13
Paris 13
Querétaro 13
Totale 12.084
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 430
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 250
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases 203
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 183
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 179
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 177
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 168
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 157
Genotoxic effects of base and prime editing in human hematopoietic stem cells 156
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 152
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 149
Genotoxicity concerns for base and prime editors in hematopoietic stem cells 144
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 141
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells 140
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 140
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 140
Long-term lineage commitment in haematopoietic stem cell gene therapy 138
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 138
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 138
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 132
Adopt a moratorium on heritable genome editing 131
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells 130
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 126
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 126
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency 124
MNK2 governs the macrophage antiinflammatory phenotype 121
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 120
GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice 119
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 119
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 118
Permanent Epigenetic Gene Silencing 115
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 115
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 113
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 113
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 112
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 111
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 110
An unbiased genome-wide analysis of zinc-finger nuclease specificity 110
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 109
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 109
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 108
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 107
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 106
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer 106
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 103
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 103
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 103
A Comeback for Gene Therapy 102
Retrieval of vector integration sites from cell-free DNA 102
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 100
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 98
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 98
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood “resident” monocytes and embryonic macrophages suggests common functions and developmental relationships 98
A gene mutatioons reinforces genotype-phenotype correlation in metachromatic leukodystrophy 97
Combining Site-Specific Integration and Cassette Design to Achieve Robust Expression Without Impacting Endogenous Gene Expression 95
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 94
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 94
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice 94
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 94
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 93
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 93
VisualZoneR: A computational protocol to identify compartmental zones from single-cell spatial transcriptomics using R 91
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 91
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 91
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 90
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 90
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer 89
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 89
Combining Targeted Integration and Cassette Design for Robust and Benign Transgene Expression without Impacting Endogenous Gene Transcription 89
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 88
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 87
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 86
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 86
HEPATOCYTE GROWTH-FACTOR IS A POTENT ANGIOGENIC FACTOR WHICH STIMULATES ENDOTHELIAL-CELL MOTILITY AND GROWTH 85
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 85
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates 85
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 84
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 84
Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates 83
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 83
IFNalpha by In Vivo-Engineered Macrophages Abates Liver Metastases and Triggers Counter Regulatory Responses Limiting Efficacy 83
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 83
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 83
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 82
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector) 82
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 81
VECTOR PRODUCTION 80
Single-cell transcriptomics uncovers cellular and molecular determinants of tissue myeloid cell heterogeneity in homeostasis and cancer 79
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 79
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. 79
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 78
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery 78
IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy 77
EXTRACELLULAR PROTEOLYTIC CLEAVAGE BY UROKINASE IS REQUIRED FOR ACTIVATION OF HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR 77
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 77
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 76
Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings 76
Methods and compositions for targeted integration 76
A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice 76
Liver-directed lentiviral gene therapy in a dog model of hemophilia B 75
Totale 11.127
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Categoria #
all - tutte 164.157
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 164.157
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022206 0 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/20241.168 42 62 138 132 116 218 43 89 10 64 78 176
2024/20255.089 554 78 68 170 209 396 671 563 818 672 442 448
2025/202616.169 1.126 1.229 1.153 2.256 1.136 504 1.478 1.196 4.439 891 329 432
2026/20271.155 446 709 0 0 0 0 0 0 0 0 0 0
Totale 25.828