IRIS
NALDINI, LUIGI
 Distribuzione geografica
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Continente #
EU - Europa 8.280
AS - Asia 7.468
NA - Nord America 5.273
SA - Sud America 1.930
AF - Africa 211
OC - Oceania 19
Totale 23.181
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Nazione #
US - Stati Uniti d'America 5.014
RU - Federazione Russa 4.848
SG - Singapore 2.750
CN - Cina 2.333
BR - Brasile 1.593
SE - Svezia 1.060
HK - Hong Kong 958
IT - Italia 817
VN - Vietnam 733
FR - Francia 392
DE - Germania 351
GB - Regno Unito 174
IN - India 169
AR - Argentina 132
CA - Canada 123
FI - Finlandia 107
AT - Austria 104
MX - Messico 93
NL - Olanda 92
ZA - Sudafrica 76
PL - Polonia 75
ID - Indonesia 70
BD - Bangladesh 68
JP - Giappone 62
EC - Ecuador 59
ES - Italia 58
IQ - Iraq 48
TR - Turchia 48
IE - Irlanda 45
CO - Colombia 38
MA - Marocco 33
UA - Ucraina 33
VE - Venezuela 28
PY - Paraguay 26
DZ - Algeria 25
PK - Pakistan 25
CL - Cile 24
LT - Lituania 21
UZ - Uzbekistan 19
CH - Svizzera 18
SA - Arabia Saudita 18
IL - Israele 17
JO - Giordania 16
KE - Kenya 16
AU - Australia 15
BE - Belgio 15
PH - Filippine 14
TN - Tunisia 14
UY - Uruguay 14
EG - Egitto 12
MY - Malesia 12
AE - Emirati Arabi Uniti 11
ET - Etiopia 11
GR - Grecia 11
DO - Repubblica Dominicana 10
KR - Corea 10
TW - Taiwan 10
IR - Iran 9
NP - Nepal 9
PE - Perù 9
AL - Albania 7
AZ - Azerbaigian 7
TH - Thailandia 7
BG - Bulgaria 6
CZ - Repubblica Ceca 6
KZ - Kazakistan 6
PS - Palestinian Territory 6
CI - Costa d'Avorio 5
JM - Giamaica 5
LB - Libano 5
BO - Bolivia 4
BY - Bielorussia 4
HN - Honduras 4
MO - Macao, regione amministrativa speciale della Cina 4
NG - Nigeria 4
PT - Portogallo 4
RO - Romania 4
AM - Armenia 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
CR - Costa Rica 3
CY - Cipro 3
DK - Danimarca 3
GE - Georgia 3
GT - Guatemala 3
HU - Ungheria 3
KG - Kirghizistan 3
LV - Lettonia 3
MK - Macedonia 3
PA - Panama 3
RS - Serbia 3
SN - Senegal 3
SY - Repubblica araba siriana 3
BB - Barbados 2
BS - Bahamas 2
DM - Dominica 2
GA - Gabon 2
GY - Guiana 2
HR - Croazia 2
KH - Cambogia 2
Totale 23.145
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Città #
Singapore 1.191
Moscow 1.069
Hong Kong 945
Ashburn 799
Dallas 767
San Jose 593
Shanghai 452
Hefei 367
Princeton 316
Lawrence 315
Lauterbourg 314
Beijing 250
Ho Chi Minh City 249
Milan 235
New York 222
São Paulo 153
Hanoi 152
Los Angeles 148
Nuremberg 101
Boardman 95
Munich 73
Orem 73
Helsinki 72
Rio de Janeiro 65
Santa Clara 62
Warsaw 55
Vienna 50
Johannesburg 49
Montreal 48
Tokyo 47
Washington 47
Brooklyn 45
Guangzhou 45
Rome 44
Cesano Boscone 43
Haiphong 41
The Dalles 41
Denver 40
Chennai 39
Dublin 39
Stockholm 38
Chicago 36
Phoenix 36
Houston 34
Curitiba 33
Frankfurt am Main 33
Brasília 32
Poplar 32
Council Bluffs 31
Da Nang 31
Atlanta 30
Belo Horizonte 29
Pune 28
Seattle 28
Mexico City 27
Toronto 26
Mumbai 24
Boston 23
Brescia 23
Tianjin 23
Turku 23
Guayaquil 22
Amsterdam 20
Columbus 20
London 20
Manchester 20
Salvador 20
Hangzhou 19
Biên Hòa 18
Campinas 18
Guarulhos 18
Tashkent 18
Hải Dương 17
Monza 17
Shenzhen 17
Turin 17
Charlotte 16
Falkenstein 16
Istanbul 16
San Francisco 16
Ankara 15
Baghdad 15
New Delhi 15
Porto Alegre 15
Quito 15
Amman 14
Jiaxing 14
Nairobi 14
Caxias do Sul 13
Montevideo 13
Paris 13
Querétaro 13
Sorocaba 13
Cambridge 12
Goiânia 12
São Gonçalo 12
Bogotá 11
Bologna 11
Dhaka 11
Franca 11
Totale 10.978
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 372
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases 183
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 168
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 165
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 161
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 158
Genotoxic effects of base and prime editing in human hematopoietic stem cells 145
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 140
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 137
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 136
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 134
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 133
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells 132
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 131
Genotoxicity concerns for base and prime editors in hematopoietic stem cells 129
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 127
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 127
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 124
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 123
Long-term lineage commitment in haematopoietic stem cell gene therapy 120
Adopt a moratorium on heritable genome editing 119
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 118
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 117
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 117
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 116
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells 115
MNK2 governs the macrophage antiinflammatory phenotype 115
GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice 110
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 110
Permanent Epigenetic Gene Silencing 108
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency 108
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 107
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 106
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 105
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 103
An unbiased genome-wide analysis of zinc-finger nuclease specificity 101
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 100
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 100
Retrieval of vector integration sites from cell-free DNA 100
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 99
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 99
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer 99
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 98
A Comeback for Gene Therapy 98
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 98
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 95
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 95
A gene mutatioons reinforces genotype-phenotype correlation in metachromatic leukodystrophy 93
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 92
Combining Site-Specific Integration and Cassette Design to Achieve Robust Expression Without Impacting Endogenous Gene Expression 92
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood “resident” monocytes and embryonic macrophages suggests common functions and developmental relationships 92
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 90
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 90
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 90
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 89
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice 89
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 89
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 89
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 88
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 87
Combining Targeted Integration and Cassette Design for Robust and Benign Transgene Expression without Impacting Endogenous Gene Transcription 86
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 85
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 85
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 84
VisualZoneR: A computational protocol to identify compartmental zones from single-cell spatial transcriptomics using R 83
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 83
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 83
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer 83
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 82
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 82
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 82
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 82
IFNalpha by In Vivo-Engineered Macrophages Abates Liver Metastases and Triggers Counter Regulatory Responses Limiting Efficacy 80
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 80
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 80
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 79
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 79
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector) 79
Single-cell transcriptomics uncovers cellular and molecular determinants of tissue myeloid cell heterogeneity in homeostasis and cancer 78
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 78
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 77
VECTOR PRODUCTION 76
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 76
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 76
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 75
Methods and compositions for targeted integration 75
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 74
HEPATOCYTE GROWTH-FACTOR IS A POTENT ANGIOGENIC FACTOR WHICH STIMULATES ENDOTHELIAL-CELL MOTILITY AND GROWTH 73
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery 73
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 73
Complete enzymatic correction of CNS tissue following intracerebral LV-mediated gene therapy in a murine model of GLD 72
IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy 71
Liver-directed lentiviral gene therapy in a dog model of hemophilia B 71
SCATTER FACTOR AND HEPATOCYTE GROWTH-FACTOR ARE INDISTINGUISHABLE LIGANDS FOR THE MET RECEPTOR 71
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia 71
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 71
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 71
Gene therapy returns to centre stage 70
IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment 70
Osteoclasts and monocytes have similar cytoskeletal structures and adhesion property in vitro. 69
Totale 10.159
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Categoria #
all - tutte 143.447
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 143.447
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20212 0 0 0 0 0 0 0 0 0 2 0 0
2021/2022207 1 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/20241.168 42 62 138 132 116 218 43 89 10 64 78 176
2024/20255.089 554 78 68 170 209 396 671 563 818 672 442 448
2025/202615.101 1.126 1.229 1.153 2.256 1.136 494 1.463 1.184 4.401 659 0 0
Totale 23.605