IRIS
NALDINI, LUIGI
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 8.472
AS - Asia 7.683
NA - Nord America 5.795
SA - Sud America 1.937
AF - Africa 214
OC - Oceania 20
Continente sconosciuto - Info sul continente non disponibili 1
Totale 24.122
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 5.488
RU - Federazione Russa 4.889
SG - Singapore 2.782
CN - Cina 2.411
BR - Brasile 1.597
SE - Svezia 1.060
HK - Hong Kong 973
IT - Italia 914
VN - Vietnam 742
FR - Francia 398
DE - Germania 355
GB - Regno Unito 204
IN - India 172
CA - Canada 150
AR - Argentina 132
BD - Bangladesh 130
FI - Finlandia 107
AT - Austria 105
MX - Messico 101
NL - Olanda 93
PL - Polonia 79
ZA - Sudafrica 77
ID - Indonesia 71
JP - Giappone 64
EC - Ecuador 59
ES - Italia 59
TR - Turchia 50
IQ - Iraq 48
IE - Irlanda 45
CO - Colombia 39
MA - Marocco 33
UA - Ucraina 33
VE - Venezuela 30
PY - Paraguay 26
DZ - Algeria 25
PK - Pakistan 25
CL - Cile 24
LT - Lituania 21
CH - Svizzera 20
UZ - Uzbekistan 20
SA - Arabia Saudita 19
IL - Israele 17
AU - Australia 16
BE - Belgio 16
JO - Giordania 16
KE - Kenya 16
MY - Malesia 16
EG - Egitto 14
PH - Filippine 14
TN - Tunisia 14
UY - Uruguay 14
AE - Emirati Arabi Uniti 13
ET - Etiopia 11
GR - Grecia 11
NP - Nepal 11
DO - Repubblica Dominicana 10
KR - Corea 10
TW - Taiwan 10
IR - Iran 9
PE - Perù 9
JM - Giamaica 8
TH - Thailandia 8
AL - Albania 7
AZ - Azerbaigian 7
BG - Bulgaria 7
CR - Costa Rica 7
CZ - Repubblica Ceca 6
KZ - Kazakistan 6
PS - Palestinian Territory 6
CI - Costa d'Avorio 5
HN - Honduras 5
LB - Libano 5
BO - Bolivia 4
BY - Bielorussia 4
DK - Danimarca 4
GT - Guatemala 4
MD - Moldavia 4
MO - Macao, regione amministrativa speciale della Cina 4
NG - Nigeria 4
PT - Portogallo 4
RO - Romania 4
AM - Armenia 3
BA - Bosnia-Erzegovina 3
BB - Barbados 3
BH - Bahrain 3
CY - Cipro 3
GE - Georgia 3
HU - Ungheria 3
KG - Kirghizistan 3
LV - Lettonia 3
MK - Macedonia 3
PA - Panama 3
RS - Serbia 3
SN - Senegal 3
SY - Repubblica araba siriana 3
BS - Bahamas 2
DM - Dominica 2
GA - Gabon 2
GY - Guiana 2
HR - Croazia 2
Totale 24.082
Salva come PNG Salva come JPEG
Città #
Singapore 1.203
Moscow 1.080
Hong Kong 959
Ashburn 830
Dallas 782
San Jose 744
Shanghai 453
Hefei 367
Lauterbourg 317
Princeton 316
Lawrence 315
New York 260
Beijing 257
Ho Chi Minh City 255
Milan 243
Los Angeles 164
São Paulo 154
Hanoi 152
Nuremberg 101
Boardman 96
Santa Clara 80
Orem 77
Munich 73
Helsinki 72
Rio de Janeiro 65
Warsaw 57
Montreal 54
Rome 52
Vienna 51
Johannesburg 49
Tokyo 47
Washington 47
Brooklyn 45
Guangzhou 45
London 44
Cesano Boscone 43
Denver 42
Haiphong 42
The Dalles 42
Chennai 39
Dublin 39
Chicago 38
Houston 38
Phoenix 38
Stockholm 38
Atlanta 36
Curitiba 34
Frankfurt am Main 34
Mexico City 34
Brasília 32
Da Nang 32
Poplar 32
Council Bluffs 31
Belo Horizonte 29
Pune 28
Seattle 28
Toronto 28
Brescia 25
Tianjin 25
Mumbai 24
Boston 23
Manchester 23
Turku 23
Guayaquil 22
Columbus 21
Amsterdam 20
Hangzhou 20
Salvador 20
Turin 20
San Francisco 19
Biên Hòa 18
Campinas 18
Guarulhos 18
Tashkent 18
Charlotte 17
Hải Dương 17
Monza 17
Shenzhen 17
Falkenstein 16
Istanbul 16
Las Vegas 16
Ankara 15
Baghdad 15
Buffalo 15
New Delhi 15
Porto Alegre 15
Quito 15
Amman 14
Jiaxing 14
Nairobi 14
Bologna 13
Caxias do Sul 13
Montevideo 13
Paris 13
Querétaro 13
Sorocaba 13
Cambridge 12
Goiânia 12
São Gonçalo 12
Bogotá 11
Totale 11.413
Salva come PNG Salva come JPEG
Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 389
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 221
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases 189
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 174
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 173
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 160
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 155
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 151
Genotoxic effects of base and prime editing in human hematopoietic stem cells 151
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 146
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 143
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells 137
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 137
Genotoxicity concerns for base and prime editors in hematopoietic stem cells 136
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 136
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 135
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 134
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 132
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 127
Long-term lineage commitment in haematopoietic stem cell gene therapy 125
Adopt a moratorium on heritable genome editing 124
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells 121
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency 121
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 121
MNK2 governs the macrophage antiinflammatory phenotype 118
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 118
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 117
GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice 116
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 116
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 114
Permanent Epigenetic Gene Silencing 112
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 111
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 109
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 107
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 107
An unbiased genome-wide analysis of zinc-finger nuclease specificity 105
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 105
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 104
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 104
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 104
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 101
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 101
Retrieval of vector integration sites from cell-free DNA 101
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer 101
A Comeback for Gene Therapy 100
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 100
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 97
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 97
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 96
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood “resident” monocytes and embryonic macrophages suggests common functions and developmental relationships 96
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 96
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 95
A gene mutatioons reinforces genotype-phenotype correlation in metachromatic leukodystrophy 94
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 93
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 93
Combining Site-Specific Integration and Cassette Design to Achieve Robust Expression Without Impacting Endogenous Gene Expression 93
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 92
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 91
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice 90
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 90
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 89
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 88
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 88
Combining Targeted Integration and Cassette Design for Robust and Benign Transgene Expression without Impacting Endogenous Gene Transcription 88
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 87
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 86
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 86
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer 86
VisualZoneR: A computational protocol to identify compartmental zones from single-cell spatial transcriptomics using R 85
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 85
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 85
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 85
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 84
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 83
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates 82
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 82
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 81
IFNalpha by In Vivo-Engineered Macrophages Abates Liver Metastases and Triggers Counter Regulatory Responses Limiting Efficacy 81
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 81
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 80
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector) 80
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 79
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 79
Single-cell transcriptomics uncovers cellular and molecular determinants of tissue myeloid cell heterogeneity in homeostasis and cancer 78
VECTOR PRODUCTION 78
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 78
HEPATOCYTE GROWTH-FACTOR IS A POTENT ANGIOGENIC FACTOR WHICH STIMULATES ENDOTHELIAL-CELL MOTILITY AND GROWTH 77
IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy 76
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 76
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 75
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. 75
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery 75
Methods and compositions for targeted integration 75
Liver-directed lentiviral gene therapy in a dog model of hemophilia B 74
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 74
Complete enzymatic correction of CNS tissue following intracerebral LV-mediated gene therapy in a murine model of GLD 73
SCATTER FACTOR AND HEPATOCYTE GROWTH-FACTOR ARE INDISTINGUISHABLE LIGANDS FOR THE MET RECEPTOR 72
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia 72
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 72
EXTRACELLULAR PROTEOLYTIC CLEAVAGE BY UROKINASE IS REQUIRED FOR ACTIVATION OF HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR 71
Totale 10.623
Salva come PNG Salva come JPEG
Categoria #
all - tutte 155.015
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 155.015
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022207 1 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/20241.168 42 62 138 132 116 218 43 89 10 64 78 176
2024/20255.089 554 78 68 170 209 396 671 563 818 672 442 448
2025/202616.052 1.126 1.229 1.153 2.256 1.136 504 1.478 1.196 4.439 891 329 315
Totale 24.556