IRIS
NALDINI, LUIGI
 Distribuzione geografica
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Continente #
AS - Asia 6.100
NA - Nord America 4.084
EU - Europa 3.148
SA - Sud America 1.789
AF - Africa 151
OC - Oceania 18
Totale 15.290
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Nazione #
US - Stati Uniti d'America 3.879
SG - Singapore 2.621
CN - Cina 1.612
BR - Brasile 1.509
SE - Svezia 1.058
HK - Hong Kong 902
IT - Italia 692
VN - Vietnam 469
RU - Federazione Russa 353
DE - Germania 311
GB - Regno Unito 136
IN - India 120
AR - Argentina 116
AT - Austria 103
FI - Finlandia 103
CA - Canada 98
MX - Messico 77
NL - Olanda 74
PL - Polonia 69
ID - Indonesia 61
ZA - Sudafrica 58
FR - Francia 55
JP - Giappone 55
EC - Ecuador 52
BD - Bangladesh 48
ES - Italia 44
IE - Irlanda 41
TR - Turchia 36
CO - Colombia 30
IQ - Iraq 29
MA - Marocco 29
UA - Ucraina 27
PY - Paraguay 23
VE - Venezuela 21
LT - Lituania 19
DZ - Algeria 18
PK - Pakistan 17
UZ - Uzbekistan 17
AU - Australia 15
IL - Israele 15
CH - Svizzera 14
CL - Cile 14
BE - Belgio 13
TN - Tunisia 12
UY - Uruguay 12
AE - Emirati Arabi Uniti 10
SA - Arabia Saudita 10
ET - Etiopia 9
KE - Kenya 9
KR - Corea 9
DO - Repubblica Dominicana 8
EG - Egitto 8
IR - Iran 8
TW - Taiwan 8
PE - Perù 7
AZ - Azerbaigian 6
JO - Giordania 6
NP - Nepal 6
BG - Bulgaria 5
KZ - Kazakistan 5
PH - Filippine 5
HN - Honduras 4
JM - Giamaica 4
AL - Albania 3
AM - Armenia 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
CZ - Repubblica Ceca 3
KG - Kirghizistan 3
LB - Libano 3
MK - Macedonia 3
MY - Malesia 3
NG - Nigeria 3
PA - Panama 3
PS - Palestinian Territory 3
RO - Romania 3
TH - Thailandia 3
BB - Barbados 2
BO - Bolivia 2
CI - Costa d'Avorio 2
DM - Dominica 2
GR - Grecia 2
GT - Guatemala 2
GY - Guiana 2
PT - Portogallo 2
RS - Serbia 2
BY - Bielorussia 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
GA - Gabon 1
GE - Georgia 1
GP - Guadalupe 1
HR - Croazia 1
KH - Cambogia 1
KW - Kuwait 1
LI - Liechtenstein 1
LV - Lettonia 1
MD - Moldavia 1
MT - Malta 1
Totale 15.278
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Città #
Singapore 1.110
Hong Kong 896
Dallas 766
Ashburn 545
Shanghai 436
Hefei 366
Princeton 316
Lawrence 315
Beijing 223
Milan 222
New York 196
Ho Chi Minh City 177
São Paulo 150
Moscow 146
Los Angeles 137
Boardman 94
Nuremberg 93
Hanoi 87
Munich 73
Helsinki 70
Rio de Janeiro 62
Warsaw 52
Vienna 49
Brooklyn 45
Cesano Boscone 43
Tokyo 43
Washington 43
Santa Clara 42
Denver 40
The Dalles 40
Johannesburg 39
Guangzhou 38
Montreal 38
Orem 38
Stockholm 37
Dublin 36
Rome 32
Curitiba 30
Haiphong 30
Phoenix 30
Poplar 29
Brasília 28
Chennai 28
Houston 28
Pune 28
Chicago 27
Seattle 27
Atlanta 25
Belo Horizonte 25
Frankfurt am Main 23
Mexico City 23
Toronto 23
Turku 23
Boston 22
Guayaquil 22
Brescia 21
Salvador 20
Columbus 19
London 19
Campinas 17
Mumbai 17
Amsterdam 16
Charlotte 16
Da Nang 16
Monza 16
Tashkent 16
Ankara 15
Council Bluffs 15
Guarulhos 15
San Francisco 15
Tianjin 15
Porto Alegre 14
Caxias do Sul 13
Jiaxing 13
Manchester 13
New Delhi 13
Querétaro 13
Sorocaba 13
Biên Hòa 12
Cambridge 12
Goiânia 12
Hải Dương 12
Quito 12
San Jose 12
São Gonçalo 12
Bogotá 11
Falkenstein 11
Franca 11
Hangzhou 11
Montevideo 11
Bergamo 10
Istanbul 10
Lappeenranta 10
Paris 10
Recife 10
Santo André 10
Baghdad 9
Dhaka 9
Genoa 9
Manaus 9
Totale 8.201
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 327
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases 124
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models 121
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 109
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 107
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias 104
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates 100
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 98
Genotoxic effects of base and prime editing in human hematopoietic stem cells 96
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells 96
Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering 95
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 91
Genotoxicity concerns for base and prime editors in hematopoietic stem cells 90
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking 88
HEPATOCYTE GROWTH-FACTOR (HGF) STIMULATES THE TYROSINE KINASE-ACTIVITY OF THE RECEPTOR ENCODED BY THE PROTOONCOGENE C-MET 87
MNK2 governs the macrophage antiinflammatory phenotype 87
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells 83
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells 83
Permanent Epigenetic Gene Silencing 81
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 81
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors 80
Genome editing: a tool for research and therapy: Targeted genome editing hits the clinic 77
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome 77
Long-term lineage commitment in haematopoietic stem cell gene therapy 76
SELECTION BY MEANS OF ARTIFICIAL TRANSACTIVATORS 76
An unbiased genome-wide analysis of zinc-finger nuclease specificity 76
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer 76
Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation 76
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice 75
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 75
Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches 74
Retrieval of vector integration sites from cell-free DNA 73
GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice 72
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 72
Adopt a moratorium on heritable genome editing 72
Safety of arylsulfatase A over-expression for gene therapy of metachromatic leukodystrophy 68
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR 67
A Comeback for Gene Therapy 67
Gene-Based Immune Reprogramming Overcomes the Immunosuppressive Microenvironment of Liver Metastases and Enables Protective T Cell Responses 66
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 65
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer 65
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells 64
'Advanced' generation lentivirruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo 64
A gene mutatioons reinforces genotype-phenotype correlation in metachromatic leukodystrophy 64
A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS 64
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. 64
ENDOGENOUS MICRORNA CAN BE BROADLY EXPLOITED TO REGULATE TRANSGENE EXPRESSION ACCORDING TO TISSUE, LINEAGE AND DIFFERENTIATION STATE 63
Combining Site-Specific Integration and Cassette Design to Achieve Robust Expression Without Impacting Endogenous Gene Expression 63
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency 61
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance 61
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer 61
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A 60
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. 58
Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice 58
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 57
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 57
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 57
Combining Targeted Integration and Cassette Design for Robust and Benign Transgene Expression without Impacting Endogenous Gene Transcription 57
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease 57
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 56
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs 56
Autologous Cell & Gene Therapy for the Therapeutic Targeting of Immune Payloads to the Solid Tumor Microenvironment: Preliminary Results of the TEM-GBM Study 55
A miRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells 55
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing 55
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 55
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells 54
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice 54
A human immunodeficiency virus type 1 pol gene-derived sequence (cPPT/CTS) increases the efficiency of transduction of human nondividing monocytes and T lymphocytes by lentiviral vectors 54
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 54
Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings 54
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 53
VECTOR PRODUCTION 53
A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors 53
SCATTER FACTOR AND HEPATOCYTE GROWTH-FACTOR ARE INDISTINGUISHABLE LIGANDS FOR THE MET RECEPTOR 53
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia 53
Single-cell transcriptomics uncovers cellular and molecular determinants of tissue myeloid cell heterogeneity in homeostasis and cancer 52
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 52
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia 52
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood “resident” monocytes and embryonic macrophages suggests common functions and developmental relationships 52
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 52
VisualZoneR: A computational protocol to identify compartmental zones from single-cell spatial transcriptomics using R 51
TYROSINES(1234-1235) ARE CRITICAL FOR ACTIVATION OF THE TYROSINE KINASE ENCODED BY THE MET PROTOONCOGENE (HGF RECEPTOR) 51
Site-specific integration and tailoring of cassette design for sustainable gene transfer 51
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector) 51
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 51
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 51
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 51
From TCR Gene Transfer to TCR Gene Editing of Central Memory T Lymphocytes for Immunotherapy of Leukemia 50
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice 50
Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes 50
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 49
IFNalpha by In Vivo-Engineered Macrophages Abates Liver Metastases and Triggers Counter Regulatory Responses Limiting Efficacy 48
Liver-directed lentiviral gene therapy in a dog model of hemophilia B 48
Osteoclasts and monocytes have similar cytoskeletal structures and adhesion property in vitro. 48
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia 48
Methods and compositions for targeted integration 48
Gene therapy returns to centre stage 47
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. 47
CD44v6 is associated with chemoresistance induced by bone marrow-derived mesenchymal stromal cells 47
Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy 47
Totale 6.874
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Categoria #
all - tutte 128.948
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 128.948
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202130 0 0 0 0 0 19 6 0 3 2 0 0
2021/2022207 1 0 0 116 10 11 12 13 12 11 5 16
2022/20231.795 700 431 128 15 11 227 49 126 61 14 19 14
2023/20241.168 42 62 138 132 116 218 43 89 10 64 78 176
2024/20255.089 554 78 68 170 209 396 671 563 818 672 442 448
2025/20267.183 1.126 1.229 1.153 2.256 1.136 283 0 0 0 0 0 0
Totale 15.687