IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
EU - Europa 7.357
AS - Asia 6.781
NA - Nord America 4.758
SA - Sud America 1.822
AF - Africa 181
OC - Oceania 23
Continente sconosciuto - Info sul continente non disponibili 4
Totale 20.926
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Nazione #
US - Stati Uniti d'America 4.544
RU - Federazione Russa 4.172
SG - Singapore 2.472
CN - Cina 2.051
BR - Brasile 1.509
IT - Italia 879
HK - Hong Kong 859
SE - Svezia 847
VN - Vietnam 691
FR - Francia 338
DE - Germania 323
GB - Regno Unito 198
IN - India 180
AR - Argentina 135
CA - Canada 106
AT - Austria 102
FI - Finlandia 101
BD - Bangladesh 84
NL - Olanda 78
PL - Polonia 78
MX - Messico 77
ES - Italia 68
ZA - Sudafrica 64
ID - Indonesia 63
EC - Ecuador 61
IQ - Iraq 60
TR - Turchia 60
JP - Giappone 59
IE - Irlanda 52
UA - Ucraina 31
CO - Colombia 30
MA - Marocco 23
LT - Lituania 22
UZ - Uzbekistan 21
AU - Australia 20
UY - Uruguay 20
VE - Venezuela 19
PY - Paraguay 17
EG - Egitto 16
PK - Pakistan 16
SA - Arabia Saudita 16
TN - Tunisia 16
JO - Giordania 15
AE - Emirati Arabi Uniti 14
CL - Cile 14
IR - Iran 14
DZ - Algeria 13
KE - Kenya 13
MY - Malesia 13
BE - Belgio 12
IL - Israele 11
NP - Nepal 10
PE - Perù 10
PH - Filippine 9
ET - Etiopia 8
JM - Giamaica 8
KR - Corea 8
AZ - Azerbaigian 7
LB - Libano 7
NG - Nigeria 7
BG - Bulgaria 6
CH - Svizzera 6
CZ - Repubblica Ceca 6
CI - Costa d'Avorio 5
LV - Lettonia 5
PS - Palestinian Territory 5
SY - Repubblica araba siriana 5
TT - Trinidad e Tobago 5
TW - Taiwan 5
BH - Bahrain 4
BO - Bolivia 4
CY - Cipro 4
DO - Repubblica Dominicana 4
GR - Grecia 4
HN - Honduras 4
MD - Moldavia 4
RO - Romania 4
RS - Serbia 4
SN - Senegal 4
AL - Albania 3
CG - Congo 3
CR - Costa Rica 3
EU - Europa 3
KW - Kuwait 3
KZ - Kazakistan 3
MT - Malta 3
AM - Armenia 2
GA - Gabon 2
GE - Georgia 2
GY - Guiana 2
KH - Cambogia 2
NA - Namibia 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PA - Panama 2
PT - Portogallo 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
TH - Thailandia 2
Totale 20.908
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Città #
Singapore 1.080
Moscow 908
Hong Kong 851
Dallas 753
Ashburn 688
San Jose 501
Shanghai 445
Hefei 327
Lauterbourg 271
Lawrence 270
Princeton 270
Beijing 257
New York 244
Milan 240
Ho Chi Minh City 230
Hanoi 154
Los Angeles 138
São Paulo 129
Nuremberg 86
Rome 82
Helsinki 70
Munich 63
Boardman 61
Orem 61
Santa Clara 61
Warsaw 61
Council Bluffs 56
Cesano Boscone 54
Tokyo 51
Brescia 50
Dublin 49
Rio de Janeiro 49
Denver 46
Brooklyn 45
Chennai 45
Vienna 44
Guangzhou 42
Haiphong 42
London 41
Stockholm 41
Frankfurt am Main 39
Johannesburg 39
Brasília 37
Poplar 36
Chicago 35
Montreal 35
Atlanta 33
Phoenix 32
Houston 30
Curitiba 29
Mexico City 28
Amsterdam 27
Guayaquil 27
The Dalles 27
Toronto 26
Pune 25
Ankara 24
Porto Alegre 24
Belo Horizonte 23
Seattle 23
Monza 22
Mumbai 22
Shenzhen 22
Washington 22
Manchester 21
Boston 20
Guarulhos 20
Salvador 20
Tashkent 20
Da Nang 19
Turku 19
Hanover 18
Turin 18
Baghdad 17
Sorocaba 17
Biên Hòa 16
Hải Dương 16
Paris 15
Tianjin 15
Amman 14
Barnet 14
Caxias do Sul 14
Montevideo 14
Querétaro 14
Quito 14
Dhaka 13
New Delhi 13
Buenos Aires 12
Hangzhou 12
Kassel 12
Charlotte 11
Istanbul 11
Lappeenranta 11
Maceió 11
Santo André 11
Wuhan 11
Campinas 10
Columbus 10
Florence 10
Fortaleza 10
Totale 10.166
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 371
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 178
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 175
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 165
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 160
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 158
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 145
Effects of atidarsagene autotemcel gene therapy on peripheral nerves in late-infantile metachromatic leukodystrophy 142
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 135
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 133
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 133
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset 128
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 126
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 123
A novel STING variant triggers endothelial toxicity and SAVI disease 123
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 121
Long-term lineage commitment in haematopoietic stem cell gene therapy 120
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 119
Access to gene therapy for rare diseases when commercialization is not fit for purpose 118
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 117
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 116
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 116
A GLB1 transgene with enhanced therapeutic potential for the preclinical development of ex-vivo gene therapy to treat mucopolysaccharidosis type IVB 114
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency 113
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 113
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 109
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 109
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 109
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 109
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 107
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 107
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 106
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 105
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 105
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 104
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 103
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 103
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 102
A glimpse into the in vivo dynamics during immune reconstitution in ADA-SCID patients after gene therapy treatment 101
Retrieval of vector integration sites from cell-free DNA 100
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 99
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 99
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 99
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 99
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 98
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 97
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 97
A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis 97
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 94
Ex Vivo and In Vivo Gene Therapy for Mucopolysaccharidoses: State of the Art 94
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 93
A map of human circular RNAs in clinically relevant tissues 92
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 92
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 92
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 91
Advances in stem cell research and therapeutic development 91
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes 91
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 90
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 90
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 89
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency 89
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 89
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 88
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 88
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 88
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 88
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 87
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 87
Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report 85
Clinical, immunological, and molecular features of typical and atypical severe combined immunodeficiency: Report of the italian primary immunodeficiency network 85
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 84
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency 84
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 83
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 83
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 83
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 82
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 82
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 82
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 82
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 82
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 81
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 80
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 80
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 80
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 80
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 79
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 79
Advances in gene therapy for ADA-deficient SCID 79
Urogenital Abnormalities in Adenosine Deaminase Deficiency 78
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy 78
Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies 77
The quality of life of children and adolescents with X-linked agammaglobulinemia 76
Persistence of circulating T-follicular helper cells after rituximab is associated with relapse of IgG4-related disease 76
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 74
Clinical applications of gene therapy for primary immunodeficiencies 74
Erratum: Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory (Science Translational Medicine (2015) 7:319 (319er9)) 74
Gene therapy using haematopoietic stem and progenitor cells 74
Overhydrated hereditary stomatocytosis: A rare cause of familiar persistent macrocytosis due to SLC4A1 variants 71
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 71
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 71
Totale 10.258
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Categoria #
all - tutte 128.676
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 128.676
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211 0 0 0 0 0 0 0 0 0 1 0 0
2021/2022228 1 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/20254.627 519 91 88 139 142 347 580 536 793 605 350 437
2025/202613.659 1.007 1.056 1.164 2.134 955 521 1.321 1.075 3.803 623 0 0
Totale 21.464