IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
AS - Asia 5.594
NA - Nord America 3.791
EU - Europa 2.855
SA - Sud America 1.696
AF - Africa 136
OC - Oceania 19
Continente sconosciuto - Info sul continente non disponibili 4
Totale 14.095
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Nazione #
US - Stati Uniti d'America 3.610
SG - Singapore 2.320
CN - Cina 1.534
BR - Brasile 1.428
SE - Svezia 844
HK - Hong Kong 810
IT - Italia 708
VN - Vietnam 417
DE - Germania 291
RU - Federazione Russa 288
GB - Regno Unito 153
IN - India 124
AR - Argentina 115
AT - Austria 100
FI - Finlandia 98
CA - Canada 91
PL - Polonia 76
NL - Olanda 67
MX - Messico 66
BD - Bangladesh 57
JP - Giappone 55
ZA - Sudafrica 55
FR - Francia 54
EC - Ecuador 52
IE - Irlanda 52
ID - Indonesia 51
IQ - Iraq 43
TR - Turchia 43
ES - Italia 42
CO - Colombia 26
UA - Ucraina 24
LT - Lituania 22
MA - Marocco 18
UY - Uruguay 17
VE - Venezuela 17
AU - Australia 16
PY - Paraguay 15
AE - Emirati Arabi Uniti 14
IR - Iran 14
UZ - Uzbekistan 14
EG - Egitto 13
DZ - Algeria 12
CL - Cile 11
PK - Pakistan 11
TN - Tunisia 11
IL - Israele 9
JO - Giordania 9
PE - Perù 9
ET - Etiopia 8
KR - Corea 8
MY - Malesia 8
AZ - Azerbaigian 6
BE - Belgio 6
JM - Giamaica 6
NG - Nigeria 6
SA - Arabia Saudita 6
BG - Bulgaria 5
KE - Kenya 5
LB - Libano 5
NP - Nepal 5
TT - Trinidad e Tobago 5
SY - Repubblica araba siriana 4
AL - Albania 3
BH - Bahrain 3
BO - Bolivia 3
CH - Svizzera 3
EU - Europa 3
HN - Honduras 3
KW - Kuwait 3
LV - Lettonia 3
PH - Filippine 3
PS - Palestinian Territory 3
AM - Armenia 2
CI - Costa d'Avorio 2
CY - Cipro 2
CZ - Repubblica Ceca 2
DO - Repubblica Dominicana 2
GE - Georgia 2
GR - Grecia 2
GY - Guiana 2
KZ - Kazakistan 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PA - Panama 2
RO - Romania 2
RS - Serbia 2
SV - El Salvador 2
TW - Taiwan 2
BW - Botswana 1
BY - Bielorussia 1
CG - Congo 1
CR - Costa Rica 1
DK - Danimarca 1
EE - Estonia 1
GA - Gabon 1
KH - Cambogia 1
MD - Moldavia 1
MK - Macedonia 1
ML - Mali 1
MN - Mongolia 1
Totale 14.083
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Città #
Singapore 988
Hong Kong 808
Dallas 752
Ashburn 483
Shanghai 430
Hefei 325
Lawrence 270
Princeton 270
New York 224
Beijing 223
Milan 210
Ho Chi Minh City 148
São Paulo 125
Los Angeles 124
Moscow 96
Nuremberg 83
Hanoi 82
Helsinki 68
Rome 64
Munich 63
Boardman 61
Warsaw 60
Cesano Boscone 54
Tokyo 50
Dublin 49
Brescia 48
Rio de Janeiro 45
Brooklyn 44
Denver 43
Vienna 43
Stockholm 39
Johannesburg 36
Poplar 36
Santa Clara 36
Brasília 35
Chennai 34
Guangzhou 34
London 34
Orem 34
Chicago 32
Montreal 32
Houston 29
Phoenix 29
Atlanta 28
Haiphong 28
Curitiba 26
Guayaquil 26
Mexico City 25
The Dalles 25
Toronto 25
Amsterdam 24
Ankara 24
Pune 24
Seattle 23
Porto Alegre 22
Belo Horizonte 21
Frankfurt am Main 21
Monza 21
Boston 20
Washington 20
Guarulhos 19
Salvador 19
Turku 19
Hanover 18
Sorocaba 17
Shenzhen 16
Mumbai 15
Caxias do Sul 14
Council Bluffs 14
Manchester 14
Querétaro 14
Tashkent 14
San Jose 13
Hải Dương 12
Paris 12
Hangzhou 11
Kassel 11
Montevideo 11
New Delhi 11
Quito 11
Turin 11
Campinas 10
Columbus 10
Fortaleza 10
Lappeenranta 10
Maceió 10
Reston 10
Santo André 10
Amman 9
Baghdad 9
Biên Hòa 9
Buenos Aires 9
Da Nang 9
Dhaka 9
Piracicaba 9
Pittsburgh 9
Recife 9
São Bernardo do Campo 9
Thái Nguyên 9
Tianjin 9
Totale 7.650
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 329
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 130
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 110
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 109
Effects of atidarsagene autotemcel gene therapy on peripheral nerves in late-infantile metachromatic leukodystrophy 107
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 106
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 104
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 99
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 93
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 92
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 91
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset 91
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 87
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 83
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 83
Access to gene therapy for rare diseases when commercialization is not fit for purpose 80
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 79
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 79
Long-term lineage commitment in haematopoietic stem cell gene therapy 78
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 77
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 77
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 77
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 77
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 76
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 75
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 75
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 74
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 74
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 74
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 73
Retrieval of vector integration sites from cell-free DNA 73
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 72
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 72
A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis 71
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 70
A GLB1 transgene with enhanced therapeutic potential for the preclinical development of ex-vivo gene therapy to treat mucopolysaccharidosis type IVB 69
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 69
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 69
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 68
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 68
A glimpse into the in vivo dynamics during immune reconstitution in ADA-SCID patients after gene therapy treatment 67
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 66
A map of human circular RNAs in clinically relevant tissues 66
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 65
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 65
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 65
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 65
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency 64
A novel STING variant triggers endothelial toxicity and SAVI disease 64
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 64
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 64
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes 64
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 62
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 62
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 61
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 61
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 61
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 60
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 60
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency 60
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 59
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 59
Advances in stem cell research and therapeutic development 59
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency 59
Ex Vivo and In Vivo Gene Therapy for Mucopolysaccharidoses: State of the Art 59
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 58
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 58
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 57
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 57
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 57
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 57
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 56
Erratum: Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory (Science Translational Medicine (2015) 7:319 (319er9)) 56
Clinical, immunological, and molecular features of typical and atypical severe combined immunodeficiency: Report of the italian primary immunodeficiency network 56
Urogenital Abnormalities in Adenosine Deaminase Deficiency 56
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 56
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 56
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 55
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 54
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 54
Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report 53
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 53
Advances in gene therapy for ADA-deficient SCID 53
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 53
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 53
The quality of life of children and adolescents with X-linked agammaglobulinemia 52
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 52
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 51
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 51
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 51
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 50
Rete IDEA: solving the unsolved diagnoses of primary immunodeficiency 50
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 50
Clinical applications of gene therapy for primary immunodeficiencies 50
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency 50
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning 50
Terapia genica e malattia ereditaria 50
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood 50
Gene therapy in rare diseases: The benefits and challenges of developing a patient-centric registry for Strimvelis in ADA-SCID 49
Treatment with rapamycin can restore regulatory T-cell function in IPEX patients 49
Totale 6.984
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Categoria #
all - tutte 117.143
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 117.143
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202140 0 0 0 0 0 18 17 0 4 1 0 0
2021/2022228 1 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/20254.627 519 91 88 139 142 347 580 536 793 605 350 437
2025/20266.749 1.007 1.056 1.164 2.134 955 433 0 0 0 0 0 0
Totale 14.554