IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
EU - Europa 7.532
AS - Asia 7.175
NA - Nord America 5.324
SA - Sud America 1.826
AF - Africa 183
OC - Oceania 23
Continente sconosciuto - Info sul continente non disponibili 4
Totale 22.067
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Nazione #
US - Stati Uniti d'America 5.062
RU - Federazione Russa 4.174
SG - Singapore 2.560
CN - Cina 2.188
BR - Brasile 1.511
IT - Italia 1.017
HK - Hong Kong 876
SE - Svezia 847
VN - Vietnam 703
FR - Francia 339
DE - Germania 324
GB - Regno Unito 201
BD - Bangladesh 200
IN - India 182
AR - Argentina 135
CA - Canada 132
AT - Austria 102
FI - Finlandia 101
MX - Messico 85
NL - Olanda 84
PL - Polonia 84
ES - Italia 69
ZA - Sudafrica 66
ID - Indonesia 65
IQ - Iraq 63
EC - Ecuador 61
JP - Giappone 60
TR - Turchia 60
IE - Irlanda 57
UA - Ucraina 31
CO - Colombia 30
MA - Marocco 23
LT - Lituania 22
MY - Malesia 22
UZ - Uzbekistan 21
AU - Australia 20
UY - Uruguay 20
VE - Venezuela 19
PY - Paraguay 17
EG - Egitto 16
PK - Pakistan 16
SA - Arabia Saudita 16
TN - Tunisia 16
AE - Emirati Arabi Uniti 15
BE - Belgio 15
JO - Giordania 15
CL - Cile 14
IR - Iran 14
JM - Giamaica 14
DZ - Algeria 13
KE - Kenya 13
NP - Nepal 12
PE - Perù 12
IL - Israele 11
PH - Filippine 9
CH - Svizzera 8
ET - Etiopia 8
KR - Corea 8
AZ - Azerbaigian 7
BG - Bulgaria 7
LB - Libano 7
MD - Moldavia 7
NG - Nigeria 7
CZ - Repubblica Ceca 6
GR - Grecia 6
TT - Trinidad e Tobago 6
TW - Taiwan 6
CI - Costa d'Avorio 5
CY - Cipro 5
LV - Lettonia 5
PS - Palestinian Territory 5
RO - Romania 5
SV - El Salvador 5
SY - Repubblica araba siriana 5
BH - Bahrain 4
BO - Bolivia 4
CR - Costa Rica 4
DO - Repubblica Dominicana 4
HN - Honduras 4
RS - Serbia 4
SN - Senegal 4
AL - Albania 3
CG - Congo 3
EU - Europa 3
KH - Cambogia 3
KW - Kuwait 3
KZ - Kazakistan 3
MT - Malta 3
TH - Thailandia 3
AM - Armenia 2
GA - Gabon 2
GE - Georgia 2
GY - Guiana 2
NA - Namibia 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PA - Panama 2
PR - Porto Rico 2
PT - Portogallo 2
SI - Slovenia 2
Totale 22.046
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Città #
Singapore 1.092
Moscow 908
Hong Kong 864
Dallas 765
Ashburn 726
San Jose 628
Shanghai 445
Hefei 327
New York 294
Lauterbourg 271
Princeton 271
Lawrence 270
Beijing 268
Milan 252
Ho Chi Minh City 235
Los Angeles 158
Hanoi 155
São Paulo 129
Rome 99
Nuremberg 86
Santa Clara 86
Helsinki 70
Munich 63
Orem 63
Warsaw 63
Boardman 62
Council Bluffs 60
Cesano Boscone 54
Dublin 54
Brooklyn 52
Tokyo 51
Brescia 50
Rio de Janeiro 50
Denver 47
Chennai 45
Vienna 44
Guangzhou 43
Haiphong 43
London 41
Stockholm 41
Chicago 39
Frankfurt am Main 39
Johannesburg 39
Atlanta 38
Brasília 37
Montreal 37
Mexico City 36
Poplar 36
Houston 35
Phoenix 35
Toronto 30
Curitiba 29
Amsterdam 27
Guayaquil 27
The Dalles 27
Pune 25
Ankara 24
Porto Alegre 24
Seattle 24
Turin 24
Washington 24
Belo Horizonte 23
Manchester 22
Monza 22
Mumbai 22
Shenzhen 22
Boston 21
Da Nang 20
Guarulhos 20
Salvador 20
Tashkent 20
Baghdad 19
Buffalo 19
Turku 19
Hanover 18
Sorocaba 17
Tianjin 17
Biên Hòa 16
Hải Dương 16
Naples 15
Paris 15
Amman 14
Barnet 14
Caxias do Sul 14
Dhaka 14
Hangzhou 14
Montevideo 14
Querétaro 14
Quito 14
Charlotte 13
Kuala Lumpur 13
New Delhi 13
Buenos Aires 12
Kassel 12
San Francisco 12
Bologna 11
Columbus 11
Istanbul 11
Kingston 11
Lappeenranta 11
Totale 10.606
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 389
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 221
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 192
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 188
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 174
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 160
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 159
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 156
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 152
Effects of atidarsagene autotemcel gene therapy on peripheral nerves in late-infantile metachromatic leukodystrophy 146
A novel STING variant triggers endothelial toxicity and SAVI disease 141
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset 141
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 139
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 137
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 134
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 131
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 127
Long-term lineage commitment in haematopoietic stem cell gene therapy 125
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 123
A GLB1 transgene with enhanced therapeutic potential for the preclinical development of ex-vivo gene therapy to treat mucopolysaccharidosis type IVB 121
Access to gene therapy for rare diseases when commercialization is not fit for purpose 120
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 120
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 119
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 119
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 118
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency 116
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 116
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 115
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 115
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 111
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 111
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 111
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 111
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 111
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 109
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 109
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 109
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 108
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 107
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 107
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 106
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 104
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 104
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 104
A glimpse into the in vivo dynamics during immune reconstitution in ADA-SCID patients after gene therapy treatment 103
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 102
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 101
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 101
A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis 101
Retrieval of vector integration sites from cell-free DNA 101
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 100
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 100
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 100
Ex Vivo and In Vivo Gene Therapy for Mucopolysaccharidoses: State of the Art 100
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 98
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 97
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 97
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes 96
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 96
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency 95
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 95
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 94
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 92
A map of human circular RNAs in clinically relevant tissues 92
Clinical, immunological, and molecular features of typical and atypical severe combined immunodeficiency: Report of the italian primary immunodeficiency network 92
Advances in stem cell research and therapeutic development 92
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 90
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 90
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 90
Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus 89
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 89
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 89
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 89
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 88
Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report 88
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 88
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 87
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 86
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 85
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 85
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency 85
Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies 84
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 84
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 84
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 83
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 83
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 83
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 82
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 81
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 81
The quality of life of children and adolescents with X-linked agammaglobulinemia 80
Advances in gene therapy for ADA-deficient SCID 80
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy 80
Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis 79
Gene therapy using haematopoietic stem and progenitor cells 78
Urogenital Abnormalities in Adenosine Deaminase Deficiency 78
Clinical applications of gene therapy for primary immunodeficiencies 77
Persistence of circulating T-follicular helper cells after rituximab is associated with relapse of IgG4-related disease 77
Targeted NGS platforms for genetic screening and gene discovery in primary immunodeficiencies 76
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 75
Totale 10.924
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Categoria #
all - tutte 141.171
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 141.171
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022228 1 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/20254.627 519 91 88 139 142 347 580 536 793 605 350 437
2025/202614.831 1.007 1.056 1.164 2.134 955 521 1.321 1.075 3.803 886 484 425
Totale 22.636