IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
EU - Europa 1.302
NA - Nord America 1.205
AS - Asia 288
OC - Oceania 13
AF - Africa 10
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 3
Totale 2.825
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Nazione #
US - Stati Uniti d'America 1.194
SE - Svezia 802
IT - Italia 274
CN - Cina 150
SG - Singapore 67
FI - Finlandia 54
DE - Germania 49
IE - Irlanda 49
IN - India 33
GB - Regno Unito 25
AU - Australia 11
FR - Francia 10
CA - Canada 9
NL - Olanda 8
RU - Federazione Russa 8
IR - Iran 7
ES - Italia 6
JP - Giappone 6
TR - Turchia 6
ET - Etiopia 5
IQ - Iraq 5
KR - Corea 5
AT - Austria 4
BE - Belgio 3
DZ - Algeria 3
EU - Europa 3
LV - Lettonia 3
MY - Malesia 3
AR - Argentina 2
BG - Bulgaria 2
BR - Brasile 2
HK - Hong Kong 2
ID - Indonesia 2
MX - Messico 2
NZ - Nuova Zelanda 2
PL - Polonia 2
BD - Bangladesh 1
CI - Costa d'Avorio 1
CZ - Repubblica Ceca 1
MK - Macedonia 1
NG - Nigeria 1
TW - Taiwan 1
UA - Ucraina 1
Totale 2.825
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Città #
Lawrence 270
Princeton 270
Ashburn 129
Shanghai 123
New York 118
Milan 111
Boardman 57
Helsinki 52
Dublin 47
Singapore 40
Pune 23
Rome 19
Hanover 18
Washington 16
Los Angeles 15
Seattle 15
London 10
Brisbane 8
Perugia 7
Aksum 5
Beijing 5
Cambridge 5
Hillah 5
Livorno 5
Rockville 5
San Jose 5
Amsterdam 4
Brescia 4
Chevy Chase 4
Delhi 4
Michaelnbach 4
Monza 4
Philadelphia 4
Verona 4
Algiers 3
Andover 3
Barcelona 3
Bethesda 3
Bologna 3
Borås 3
Cagliari 3
Castelseprio 3
Ercolano 3
Gijang-gun 3
Kuala Lumpur 3
Loughton 3
Moorestown 3
Park City 3
Riga 3
Santa Clara 3
Secaucus 3
St Petersburg 3
Toronto 3
Athlone 2
Aurora 2
Belluno 2
Berlin 2
Bisceglie 2
Bristol 2
Brooklyn 2
Buenos Aires 2
Bursa 2
Campobasso 2
Casier 2
Cherry Hill 2
Chicago 2
Council Bluffs 2
Crema 2
Dayton 2
Daytona Beach 2
Düsseldorf 2
Elmendorf 2
Farmington 2
Gustavo Adolfo Madero 2
Hamilton 2
Hangzhou 2
Hong Kong 2
Hyderabad 2
Kingston upon Thames 2
Langhirano 2
Lappeenranta 2
Las Vegas 2
Laurel 2
Limbiate 2
Madrid 2
Malnate 2
Merkez 2
Mountain View 2
Newtown 2
Orlando 2
Palo Alto 2
Paris 2
Pisa 2
Plovdiv 2
Reggio Emilia 2
Roslindale 2
Ruislip 2
Salerno 2
Sant'Andrea Bagni 2
Schaarbeek 2
Totale 1.566
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 184
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 57
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 45
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 25
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 25
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 24
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 24
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 24
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 24
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 23
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 22
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 22
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 21
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 21
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 21
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 21
Linee Guida per la diagnosi e terapia dell’Immunodeficienza Comune Variabile 20
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia 20
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 20
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 20
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 19
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 19
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 19
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 18
T Cell Suicide Gene Therapy Prompts Thymic Renewal in Adults After Haploidentical Hematopoietic Stem Cell Transplantation in the Absence of Post-Transplant Immunesuppression 18
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 18
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 18
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 17
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 17
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 17
Urogenital Abnormalities in Adenosine Deaminase Deficiency 17
Retrieval of vector integration sites from cell-free DNA 17
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 17
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 17
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 17
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 17
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 16
Interleukin 7 production by bone marrow-derived stromal cells in HIV-1-infected patients during highly active antiretroviral therapy 16
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 16
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 16
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 16
Gene therapy using haematopoietic stem and progenitor cells 16
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 16
Control of human coagulation by recombinant serine proteases. Blood clotting is activated by recombinant factor XII deleted of five regulatory domains 15
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 15
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 15
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 15
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 15
Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: Analysis of function and distribution in lymphoid organs 15
JAK3 mutations in Italian patients affected by SCID: New molecular aspects of a long-known gene 15
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 15
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 15
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 15
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 15
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 15
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 14
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 14
Hematopoietic support and cytokine expression of murine-stable hepatocyte cell lines (MMH) 14
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 14
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 14
A map of human circular RNAs in clinically relevant tissues 14
In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells 14
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 14
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 14
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 14
Persistence of circulating T-follicular helper cells after rituximab is associated with relapse of IgG4-related disease 14
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 13
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 13
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 13
Identification of distinct elements of the stromal microenvironment that control human hematopoietic stem/progenitor cell growth and differentiation 13
Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation 13
Spectrotype of anti-gp120 antibodies remains stable during the course of HIV disease 13
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood 13
Erratum: Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory (Science Translational Medicine (2015) 7:319 (319er9)) 13
Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug 13
Neutrophils drive type-I interferon production and autoantibodies in Wiskott-Aldrich syndrome 13
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 13
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy 13
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 13
Gene therapy in pediatrics 12
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 12
Clinical applications of gene therapy for primary immunodeficiencies 12
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 12
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency 12
Terapia genica e malattia ereditaria 12
In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases 12
Clinical improvement and normalized Th1 cytokine profile in early and long-term Interferon-alpha treatment in a suspected case of Hyper-IgE Syndrome 12
Disease evolution and response to rapamycin in activated phosphoinositide 3-kinase δ syndrome: The European society for immunodeficiencies-activated phosphoinositide 3-kinase δ syndrome registry 12
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 12
LENTIVIRAL VECTOR TRANSDUCED CD34+CELLS FOR THE TREATMENT OF WISKOTT-ALDRICH SYNDROME 12
Good Laboratory Practice Preclinical Safety Studies for GSK2696273 (MLV Vector-Based Ex Vivo Gene Therapy for Adenosine Deaminase Deficiency Severe Combined Immunodeficiency) in NSG Mice 12
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 12
Management options for adenosine deaminase deficiency; proceedings of the EBMT satellite workshop (Hamburg, March 2006) 12
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 12
Access to gene therapy for rare diseases when commercialization is not fit for purpose 11
Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors 11
Lack of evidence for a superantigen in lymphocytes from HIV-discordant monozygotic twins 11
Purine metabolism, immune reconstitution, and abdominal adipose tumor after gene therapy for adenosine deaminase deficiency 11
Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell 11
Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement 11
Totale 1.806
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Categoria #
all - tutte 54.286
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.286
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202052 21 0 0 4 0 1 0 4 0 22 0 0
2020/202162 5 2 1 0 14 18 17 0 4 1 0 0
2021/2022228 1 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/202512 12 0 0 0 0 0 0 0 0 0 0 0
Totale 3.190