IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
AS - Asia 5.523
NA - Nord America 3.586
EU - Europa 2.808
SA - Sud America 1.675
AF - Africa 131
OC - Oceania 19
Continente sconosciuto - Info sul continente non disponibili 4
Totale 13.746
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Nazione #
US - Stati Uniti d'America 3.421
SG - Singapore 2.302
CN - Cina 1.522
BR - Brasile 1.414
SE - Svezia 839
HK - Hong Kong 805
IT - Italia 696
VN - Vietnam 415
DE - Germania 290
RU - Federazione Russa 288
GB - Regno Unito 145
IN - India 113
AR - Argentina 111
AT - Austria 100
FI - Finlandia 98
CA - Canada 83
PL - Polonia 67
NL - Olanda 63
MX - Messico 59
BD - Bangladesh 55
FR - Francia 54
IE - Irlanda 52
ZA - Sudafrica 52
EC - Ecuador 51
ID - Indonesia 51
JP - Giappone 49
TR - Turchia 40
IQ - Iraq 39
ES - Italia 37
CO - Colombia 26
UA - Ucraina 23
LT - Lituania 21
MA - Marocco 18
UY - Uruguay 17
AU - Australia 16
VE - Venezuela 16
IR - Iran 14
PY - Paraguay 14
UZ - Uzbekistan 14
AE - Emirati Arabi Uniti 13
EG - Egitto 13
DZ - Algeria 12
CL - Cile 11
TN - Tunisia 11
IL - Israele 9
PE - Perù 9
PK - Pakistan 9
KR - Corea 8
MY - Malesia 8
ET - Etiopia 7
JO - Giordania 7
AZ - Azerbaigian 6
BE - Belgio 6
JM - Giamaica 6
BG - Bulgaria 5
KE - Kenya 5
LB - Libano 5
NG - Nigeria 5
NP - Nepal 5
SA - Arabia Saudita 5
TT - Trinidad e Tobago 5
SY - Repubblica araba siriana 4
AL - Albania 3
BO - Bolivia 3
CH - Svizzera 3
EU - Europa 3
HN - Honduras 3
KW - Kuwait 3
LV - Lettonia 3
PH - Filippine 3
PS - Palestinian Territory 3
BH - Bahrain 2
CI - Costa d'Avorio 2
CY - Cipro 2
CZ - Repubblica Ceca 2
DO - Repubblica Dominicana 2
GE - Georgia 2
GR - Grecia 2
GY - Guiana 2
KZ - Kazakistan 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
RO - Romania 2
RS - Serbia 2
SV - El Salvador 2
TW - Taiwan 2
AM - Armenia 1
BW - Botswana 1
BY - Bielorussia 1
CG - Congo 1
CR - Costa Rica 1
DK - Danimarca 1
EE - Estonia 1
GA - Gabon 1
KH - Cambogia 1
MK - Macedonia 1
ML - Mali 1
MN - Mongolia 1
MT - Malta 1
NA - Namibia 1
Totale 13.735
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Città #
Singapore 970
Hong Kong 803
Dallas 750
Ashburn 442
Shanghai 430
Hefei 325
Lawrence 270
Princeton 270
Beijing 223
Milan 209
New York 205
Ho Chi Minh City 147
São Paulo 122
Los Angeles 106
Moscow 96
Nuremberg 83
Hanoi 82
Helsinki 68
Munich 63
Rome 63
Boardman 61
Cesano Boscone 54
Warsaw 52
Dublin 49
Brescia 47
Rio de Janeiro 44
Tokyo 44
Vienna 43
Brooklyn 40
Denver 38
Brasília 35
Guangzhou 34
Stockholm 34
Johannesburg 33
London 33
Poplar 32
Santa Clara 30
Chennai 28
Haiphong 28
Chicago 27
Montreal 27
Phoenix 26
Curitiba 25
Guayaquil 25
The Dalles 25
Pune 24
Houston 23
Mexico City 23
Toronto 23
Porto Alegre 22
Amsterdam 21
Ankara 21
Atlanta 21
Belo Horizonte 21
Frankfurt am Main 21
Monza 21
Seattle 21
Washington 20
Salvador 19
Turku 19
Boston 18
Guarulhos 18
Hanover 18
Sorocaba 17
Shenzhen 16
Orem 15
Caxias do Sul 14
Tashkent 14
Manchester 13
Mumbai 13
Hải Dương 12
Paris 12
Hangzhou 11
Kassel 11
Montevideo 11
Quito 11
Campinas 10
Columbus 10
Council Bluffs 10
Fortaleza 10
Lappeenranta 10
Maceió 10
Querétaro 10
Reston 10
Santo André 10
Biên Hòa 9
Buenos Aires 9
Da Nang 9
New Delhi 9
Piracicaba 9
Pittsburgh 9
Recife 9
São Bernardo do Campo 9
Thái Nguyên 9
Tianjin 9
Turin 9
Baghdad 8
Bogotá 8
Brisbane 8
Cambridge 8
Totale 7.406
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 326
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 130
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 109
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 106
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 105
Effects of atidarsagene autotemcel gene therapy on peripheral nerves in late-infantile metachromatic leukodystrophy 104
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 100
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 97
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 90
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 90
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 90
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset 90
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 85
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 81
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 81
Access to gene therapy for rare diseases when commercialization is not fit for purpose 78
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 77
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 77
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 77
Long-term lineage commitment in haematopoietic stem cell gene therapy 76
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 76
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 75
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 75
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 74
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 74
Retrieval of vector integration sites from cell-free DNA 73
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 72
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 72
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 72
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 72
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 72
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 71
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 70
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 69
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 68
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 67
A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis 67
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 67
A glimpse into the in vivo dynamics during immune reconstitution in ADA-SCID patients after gene therapy treatment 66
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 65
A GLB1 transgene with enhanced therapeutic potential for the preclinical development of ex-vivo gene therapy to treat mucopolysaccharidosis type IVB 65
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 65
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 65
A map of human circular RNAs in clinically relevant tissues 65
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 64
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes 64
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 64
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 64
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency 62
A novel STING variant triggers endothelial toxicity and SAVI disease 62
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 62
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 62
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 62
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 60
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 60
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 60
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 59
Advances in stem cell research and therapeutic development 59
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 59
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 58
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 58
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency 58
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 58
Ex Vivo and In Vivo Gene Therapy for Mucopolysaccharidoses: State of the Art 57
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency 57
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 56
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 56
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 56
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 56
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 55
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 55
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 55
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 54
Erratum: Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory (Science Translational Medicine (2015) 7:319 (319er9)) 54
Clinical, immunological, and molecular features of typical and atypical severe combined immunodeficiency: Report of the italian primary immunodeficiency network 54
Urogenital Abnormalities in Adenosine Deaminase Deficiency 54
Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report 53
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 53
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 52
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 52
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 52
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 52
The quality of life of children and adolescents with X-linked agammaglobulinemia 51
Advances in gene therapy for ADA-deficient SCID 51
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 51
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 51
Rete IDEA: solving the unsolved diagnoses of primary immunodeficiency 50
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 50
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 50
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial 50
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 50
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 49
Clinical applications of gene therapy for primary immunodeficiencies 49
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency 49
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning 49
Terapia genica e malattia ereditaria 49
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood 49
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 48
Gene therapy in rare diseases: The benefits and challenges of developing a patient-centric registry for Strimvelis in ADA-SCID 48
Gene therapy using haematopoietic stem and progenitor cells 48
Totale 6.826
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Categoria #
all - tutte 115.136
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 115.136
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202140 0 0 0 0 0 18 17 0 4 1 0 0
2021/2022228 1 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/20254.627 519 91 88 139 142 347 580 536 793 605 350 437
2025/20266.400 1.007 1.056 1.164 2.134 955 84 0 0 0 0 0 0
Totale 14.205