IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
EU - Europa 7.776
AS - Asia 7.426
NA - Nord America 6.381
SA - Sud America 1.845
Continente sconosciuto - Info sul continente non disponibili 593
AF - Africa 187
OC - Oceania 24
Totale 24.232
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Nazione #
US - Stati Uniti d'America 6.040
RU - Federazione Russa 4.174
SG - Singapore 2.588
CN - Cina 2.268
BR - Brasile 1.514
IT - Italia 1.235
HK - Hong Kong 891
SE - Svezia 847
VN - Vietnam 711
FR - Francia 345
DE - Germania 326
BD - Bangladesh 291
GB - Regno Unito 203
IN - India 186
CA - Canada 162
AR - Argentina 136
AT - Austria 102
FI - Finlandia 101
MX - Messico 87
NL - Olanda 87
PL - Polonia 84
ES - Italia 77
ID - Indonesia 70
ZA - Sudafrica 67
EC - Ecuador 65
JP - Giappone 65
IQ - Iraq 63
TR - Turchia 62
IE - Irlanda 57
CO - Colombia 37
UA - Ucraina 33
MY - Malesia 28
MA - Marocco 23
VE - Venezuela 23
JM - Giamaica 22
LT - Lituania 22
AU - Australia 21
UZ - Uzbekistan 21
UY - Uruguay 20
PY - Paraguay 17
TN - Tunisia 17
EG - Egitto 16
PK - Pakistan 16
SA - Arabia Saudita 16
AE - Emirati Arabi Uniti 15
BE - Belgio 15
JO - Giordania 15
CL - Cile 14
DZ - Algeria 14
IR - Iran 14
CR - Costa Rica 13
KE - Kenya 13
NP - Nepal 13
HN - Honduras 12
PE - Perù 12
TT - Trinidad e Tobago 12
IL - Israele 11
KR - Corea 11
PH - Filippine 10
CH - Svizzera 8
ET - Etiopia 8
AZ - Azerbaigian 7
BG - Bulgaria 7
CZ - Repubblica Ceca 7
LB - Libano 7
MD - Moldavia 7
NG - Nigeria 7
TW - Taiwan 7
GR - Grecia 6
NI - Nicaragua 6
SV - El Salvador 6
CI - Costa d'Avorio 5
CY - Cipro 5
GT - Guatemala 5
LV - Lettonia 5
PR - Porto Rico 5
PS - Palestinian Territory 5
RO - Romania 5
SY - Repubblica araba siriana 5
BH - Bahrain 4
BO - Bolivia 4
DO - Repubblica Dominicana 4
RS - Serbia 4
SN - Senegal 4
TH - Thailandia 4
AL - Albania 3
CG - Congo 3
EU - Europa 3
KH - Cambogia 3
KW - Kuwait 3
KZ - Kazakistan 3
MT - Malta 3
PA - Panama 3
PT - Portogallo 3
AM - Armenia 2
BB - Barbados 2
EE - Estonia 2
GA - Gabon 2
GD - Grenada 2
GE - Georgia 2
Totale 23.616
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Città #
Singapore 1.117
Moscow 909
Hong Kong 879
Dallas 776
Ashburn 768
San Jose 664
Shanghai 447
Council Bluffs 415
Hefei 327
New York 312
Beijing 298
Milan 295
Lauterbourg 271
Princeton 271
Lawrence 270
Ho Chi Minh City 235
Los Angeles 175
Hanoi 160
Santa Clara 159
Rome 132
São Paulo 129
Nuremberg 86
Helsinki 70
Orem 64
Munich 63
Warsaw 63
Boardman 62
Brescia 57
Brooklyn 56
Cesano Boscone 54
Dublin 54
Tokyo 51
Rio de Janeiro 50
Denver 47
Chicago 46
Phoenix 46
Chennai 45
Vienna 45
Guangzhou 43
Haiphong 43
London 43
Montreal 42
Atlanta 41
Frankfurt am Main 41
Stockholm 41
Houston 40
Johannesburg 40
Brasília 37
Mexico City 37
Poplar 36
Boston 33
Toronto 33
Curitiba 29
Guayaquil 29
Seattle 29
The Dalles 29
Washington 28
Amsterdam 27
Turin 27
Buffalo 26
Mumbai 26
Pune 25
Ankara 24
Naples 24
Porto Alegre 24
Belo Horizonte 23
Da Nang 22
Manchester 22
Monza 22
Shenzhen 22
Guarulhos 20
Salvador 20
Tashkent 20
Baghdad 19
Bologna 19
Turku 19
Hanover 18
Tianjin 18
Kuala Lumpur 17
San Francisco 17
Sorocaba 17
Biên Hòa 16
Hải Dương 16
Philadelphia 16
Charlotte 15
Dhaka 15
Kingston 15
Paris 15
Quito 15
Amman 14
Barnet 14
Caxias do Sul 14
Florence 14
Hangzhou 14
Montevideo 14
Omaha 14
Querétaro 14
New Delhi 13
Buenos Aires 12
Genoa 12
Totale 11.452
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 430
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 269
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 250
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 199
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking 183
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 177
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 168
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 161
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 159
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset 151
A novel STING variant triggers endothelial toxicity and SAVI disease 150
Effects of atidarsagene autotemcel gene therapy on peripheral nerves in late-infantile metachromatic leukodystrophy 149
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 143
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 141
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 139
Long-term lineage commitment in haematopoietic stem cell gene therapy 138
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 138
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 135
A GLB1 transgene with enhanced therapeutic potential for the preclinical development of ex-vivo gene therapy to treat mucopolysaccharidosis type IVB 133
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 132
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 129
Ex Vivo and In Vivo Gene Therapy for Mucopolysaccharidoses: State of the Art 128
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 127
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 126
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 126
Access to gene therapy for rare diseases when commercialization is not fit for purpose 123
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency 122
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 122
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 119
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 119
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 117
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 116
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study 115
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 115
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 113
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 113
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 112
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 112
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 112
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 112
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 112
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 111
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 110
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy 109
A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis 108
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 107
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 107
Targeted NGS platforms for genetic screening and gene discovery in primary immunodeficiencies 107
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 107
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 106
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 105
A glimpse into the in vivo dynamics during immune reconstitution in ADA-SCID patients after gene therapy treatment 105
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 105
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 105
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome 103
Clinical, immunological, and molecular features of typical and atypical severe combined immunodeficiency: Report of the italian primary immunodeficiency network 103
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 102
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 102
Retrieval of vector integration sites from cell-free DNA 102
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes 102
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 101
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 100
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders 100
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency 99
Defective B cell tolerance due to adenosine deaminase deficiency is corrected by gene therapy 97
Advances in stem cell research and therapeutic development 96
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 96
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 94
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 94
Gene therapy using haematopoietic stem and progenitor cells 94
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 94
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy 93
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 93
A map of human circular RNAs in clinically relevant tissues 93
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 93
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency 93
Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus 92
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 92
Natural history of type 1 diabetes on an immunodysregulatory background with genetic alteration in B-cell activating factor receptor: A case report 91
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 91
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 91
Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies 90
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 90
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 90
Relevance of an Academic GMP Pan-European Vector Infra-structure (PEVI) 89
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy 89
Human genetic and immunological determinants of critical COVID-19 pneumonia 89
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 88
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 87
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 86
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 86
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 85
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 85
The quality of life of children and adolescents with X-linked agammaglobulinemia 84
Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis 84
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 84
Advanced cell-based therapies for the treatment of primary immunodeficiency (Cell-PID) 83
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 83
Advances in gene therapy for ADA-deficient SCID 81
Urogenital Abnormalities in Adenosine Deaminase Deficiency 81
Totale 11.662
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Categoria #
all - tutte 151.302
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 151.302
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022227 0 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/20254.627 519 91 88 139 142 347 580 536 793 605 350 437
2025/202614.969 1.007 1.056 1.164 2.134 955 521 1.321 1.075 3.803 886 484 563
2026/20271.458 703 755 0 0 0 0 0 0 0 0 0 0
Totale 24.232