IRIS
AIUTI, ALESSANDRO
 Distribuzione geografica
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Continente #
AS - Asia 2.432
EU - Europa 2.196
NA - Nord America 1.496
SA - Sud America 411
AF - Africa 26
OC - Oceania 16
Continente sconosciuto - Info sul continente non disponibili 4
Totale 6.581
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Nazione #
US - Stati Uniti d'America 1.466
SG - Singapore 961
SE - Svezia 806
HK - Hong Kong 692
CN - Cina 626
IT - Italia 596
BR - Brasile 379
RU - Federazione Russa 268
DE - Germania 189
AT - Austria 74
FI - Finlandia 72
IE - Irlanda 50
IN - India 45
GB - Regno Unito 42
NL - Olanda 42
CA - Canada 16
IQ - Iraq 15
TR - Turchia 15
AU - Australia 14
FR - Francia 13
ES - Italia 12
IR - Iran 12
MX - Messico 10
JP - Giappone 9
AR - Argentina 8
VE - Venezuela 7
BE - Belgio 6
KR - Corea 6
BD - Bangladesh 5
CL - Cile 5
ET - Etiopia 5
IL - Israele 5
UY - Uruguay 5
ZA - Sudafrica 5
BG - Bulgaria 4
DZ - Algeria 4
MA - Marocco 4
PL - Polonia 4
SY - Repubblica araba siriana 4
UA - Ucraina 4
UZ - Uzbekistan 4
VN - Vietnam 4
EC - Ecuador 3
EG - Egitto 3
EU - Europa 3
LT - Lituania 3
LV - Lettonia 3
MY - Malesia 3
PK - Pakistan 3
PS - Palestinian Territory 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
CO - Colombia 2
GE - Georgia 2
ID - Indonesia 2
JM - Giamaica 2
LB - Libano 2
NP - Nepal 2
NZ - Nuova Zelanda 2
PE - Perù 2
TN - Tunisia 2
TW - Taiwan 2
AM - Armenia 1
AZ - Azerbaigian 1
CI - Costa d'Avorio 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
EE - Estonia 1
JO - Giordania 1
KE - Kenya 1
KW - Kuwait 1
MK - Macedonia 1
MN - Mongolia 1
NG - Nigeria 1
NI - Nicaragua 1
OM - Oman 1
PH - Filippine 1
RO - Romania 1
RS - Serbia 1
SA - Arabia Saudita 1
SI - Slovenia 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 6.581
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Città #
Hong Kong 690
Shanghai 427
Singapore 271
Lawrence 270
Princeton 270
Milan 187
Ashburn 145
New York 122
Moscow 96
Nuremberg 68
Helsinki 64
Boardman 57
Cesano Boscone 54
Rome 51
Dublin 48
Brescia 47
Vienna 32
São Paulo 26
Guangzhou 23
Pune 23
Los Angeles 22
Monza 21
Washington 19
Hanover 18
Beijing 17
London 17
Dallas 16
Seattle 15
Shenzhen 14
Amsterdam 11
Belo Horizonte 11
Brasília 10
Frankfurt am Main 10
Kassel 10
Reston 9
Turin 9
Brisbane 8
Rio de Janeiro 8
Santa Clara 8
Lappeenranta 7
Perugia 7
Bologna 6
Falkenstein 6
Porto Alegre 6
Reggio Emilia 6
Aksum 5
Cambridge 5
Chicago 5
Florence 5
Fremont 5
Guarulhos 5
Hefei 5
Hillah 5
Livorno 5
Maceió 5
Naples 5
Rockville 5
Salvador 5
San Jose 5
Sorocaba 5
Toronto 5
Xi'an 5
Ankara 4
Bengaluru 4
Bergamo 4
Brussels 4
Chevy Chase 4
Cornate d'Adda 4
Delhi 4
Hamburg 4
Hangzhou 4
Istanbul 4
Madrid 4
Manassas 4
Michaelnbach 4
Paris 4
Philadelphia 4
Rishon LeTsiyyon 4
Santo André 4
St Petersburg 4
Sydney 4
São Carlos 4
Tashkent 4
Tokyo 4
Verona 4
Wuhan 4
Wuxi 4
Algiers 3
Andover 3
Badalona 3
Barcelona 3
Belford Roxo 3
Berlin 3
Bethesda 3
Borås 3
Buenos Aires 3
Cagliari 3
Campinas 3
Castelseprio 3
Chandigarh 3
Totale 3.486
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Nome #
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy 265
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 69
Gene therapy for immunodeficiency due to adenosine deaminase deficiency 66
Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency 62
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access 58
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 58
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress 55
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 52
Hematopoietic stem-and progenitor-cell gene therapy for hurler syndrome 49
Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity 48
Retrieval of vector integration sites from cell-free DNA 47
Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice 46
A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease 44
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series 40
A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID 40
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency 39
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency 38
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy 37
Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy 37
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity 37
Wiskott–Aldrich syndrome: Oral findings and microbiota in children and review of the literature 37
Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 37
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency 36
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection 36
Metachromatic leukodystrophy: A single-center longitudinal study of 45 patients 36
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 36
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis 36
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 36
AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells 34
A novel genomic inversion in Wiskott-Aldrich-associated autoinflammation 34
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency 34
B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients 34
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation 34
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 34
Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory 33
Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients 33
A Case of Two Adult Brothers with Wiskott-Aldrich Syndrome, One Treated with Gene Therapy and One with HLA-Identical Hematopoietic Stem Cell Transplantation 33
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 32
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 32
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome 31
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia 31
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 31
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report 31
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency 31
Access to gene therapy for rare diseases when commercialization is not fit for purpose 30
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome 30
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects 30
Corrigendum: Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies 30
Pioglitazone as a novel therapeutic approach in chronic granulomatous disease 30
Coronavirus disease 2019 in patients with inborn errors of immunity: An international study 30
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System 30
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy 30
Ex Vivo and In Vivo Gene Therapy for Mucopolysaccharidoses: State of the Art 30
An innovative platform approach for the development of ex-vivo gene therapies for the treatment of lysosomal storage diseases with skeletal involvement 30
Linee Guida per la diagnosi e terapia dell’Immunodeficienza Comune Variabile 29
A map of human circular RNAs in clinically relevant tissues 29
Urogenital Abnormalities in Adenosine Deaminase Deficiency 29
Third cranial nerve palsy in an 88-year-old man after SARS-CoV-2 mRNA vaccination: Change of injection site and type of vaccine resulted in an uneventful second dose with humoral immune response 29
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy 28
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs. 28
Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients 28
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning 28
Terapia genica e malattia ereditaria 28
T Cell Suicide Gene Therapy Prompts Thymic Renewal in Adults After Haploidentical Hematopoietic Stem Cell Transplantation in the Absence of Post-Transplant Immunesuppression 28
Treatment with rapamycin can restore regulatory T-cell function in IPEX patients 28
Gene therapy using haematopoietic stem and progenitor cells 28
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome 28
Up to 10.5 Years of Follow-Up in 17 Subjects Treated with Hematopoietic Stem and Progenitor Cell Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome 27
Correction to: A Case of Two Adult Brothers with Wiskott‑Aldrich Syndrome, One Treated with Gene Therapy and One with HLA‑Identical Hematopoietic Stem Cell Transplantation (Journal of Clinical Immunology, (2022), 42, 2, (421-425), 10.1007/s10875-021-01157-6) 27
Identification of distinct elements of the stromal microenvironment that control human hematopoietic stem/progenitor cell growth and differentiation 27
Interleukin 7 production by bone marrow-derived stromal cells in HIV-1-infected patients during highly active antiretroviral therapy 27
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate 27
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood 27
Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus 27
Leukocyte and Dried Blood Spot Arylsulfatase A Assay by Tandem Mass Spectrometry 27
Clinical, immunological, and molecular features of typical and atypical severe combined immunodeficiency: Report of the italian primary immunodeficiency network 27
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency 27
Persistence of circulating T-follicular helper cells after rituximab is associated with relapse of IgG4-related disease 27
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) 26
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells 26
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome. 26
Gene therapy in rare diseases: The benefits and challenges of developing a patient-centric registry for Strimvelis in ADA-SCID 26
First case of patient with two homozygous mutations in MYD88 and CARD9 genes presenting with pyogenic bacterial infections, elevated IgE, and persistent EBV viremia 26
Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis 26
The Role of Conditioning in Hematopoietic Stem-Cell Gene Therapy 26
Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity 26
Immunosuppressive therapy in childhood‐onset arrhythmogenic inflammatory cardiomyopathy 26
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients 26
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency 26
Cell-surface marking of CD(34+)-restricted phenotypes of human hematopoietic progenitor cells by retrovirus-mediated gene transfer 25
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors 25
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID 25
Clinical applications of gene therapy for primary immunodeficiencies 25
A glimpse into the in vivo dynamics during immune reconstitution in ADA-SCID patients after gene therapy treatment 25
Impaired X-CGD T cell compartment is gp91phox-NADPH oxidase independent 25
JAK3 mutations in Italian patients affected by SCID: New molecular aspects of a long-known gene 25
Circulating follicular helper and follicular regulatory T cells are severely compromised in human CD40 deficiency: A case report 25
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset 25
Long-term lineage commitment in haematopoietic stem cell gene therapy 24
Updated Management Guidelines for Adenosine Deaminase Deficiency 24
Totale 3.523
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Categoria #
all - tutte 88.598
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 88.598
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202022 0 0 0 0 0 0 0 0 0 22 0 0
2020/202162 5 2 1 0 14 18 17 0 4 1 0 0
2021/2022228 1 0 2 62 19 9 17 16 31 52 13 6
2022/20231.630 607 346 108 26 21 194 61 104 85 22 26 30
2023/20241.104 83 56 117 114 89 201 44 87 9 53 62 189
2024/20253.832 519 91 88 139 142 347 580 536 793 597 0 0
Totale 7.010