IRIS
GUIDOTTI, LUCA
 Distribuzione geografica
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Continente #
EU - Europa 3.704
AS - Asia 3.403
NA - Nord America 2.173
SA - Sud America 772
AF - Africa 79
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 1
Totale 10.141
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Nazione #
RU - Federazione Russa 2.206
US - Stati Uniti d'America 2.059
SG - Singapore 1.224
CN - Cina 1.099
BR - Brasile 619
SE - Svezia 547
HK - Hong Kong 436
IT - Italia 319
VN - Vietnam 311
FR - Francia 160
DE - Germania 142
BD - Bangladesh 94
GB - Regno Unito 79
AR - Argentina 66
IN - India 55
CA - Canada 47
FI - Finlandia 46
AT - Austria 41
MX - Messico 41
ID - Indonesia 40
PL - Polonia 40
IQ - Iraq 29
NL - Olanda 29
EC - Ecuador 28
CO - Colombia 24
ZA - Sudafrica 24
IE - Irlanda 17
TR - Turchia 17
ES - Italia 16
PK - Pakistan 14
GH - Ghana 13
UA - Ucraina 11
JP - Giappone 10
PY - Paraguay 10
AU - Australia 9
CL - Cile 9
SA - Arabia Saudita 9
CH - Svizzera 8
MA - Marocco 8
AE - Emirati Arabi Uniti 7
PH - Filippine 7
RO - Romania 7
UZ - Uzbekistan 7
VE - Venezuela 7
BE - Belgio 6
AL - Albania 5
DZ - Algeria 5
IR - Iran 5
TW - Taiwan 5
BO - Bolivia 4
CZ - Repubblica Ceca 4
EG - Egitto 4
JM - Giamaica 4
KE - Kenya 4
LB - Libano 4
LT - Lituania 4
MY - Malesia 4
RS - Serbia 4
CR - Costa Rica 3
ET - Etiopia 3
HN - Honduras 3
IL - Israele 3
KZ - Kazakistan 3
MK - Macedonia 3
NP - Nepal 3
TH - Thailandia 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AO - Angola 2
BA - Bosnia-Erzegovina 2
CG - Congo 2
DO - Repubblica Dominicana 2
KH - Cambogia 2
KN - Saint Kitts e Nevis 2
KR - Corea 2
NI - Nicaragua 2
OM - Oman 2
PA - Panama 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
SZ - Regno dello Swaziland 2
YE - Yemen 2
AZ - Azerbaigian 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BS - Bahamas 1
BW - Botswana 1
CD - Congo 1
CI - Costa d'Avorio 1
DK - Danimarca 1
GA - Gabon 1
GD - Grenada 1
GE - Georgia 1
GY - Guiana 1
JO - Giordania 1
LV - Lettonia 1
LY - Libia 1
Totale 10.132
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Città #
Singapore 494
Moscow 433
Hong Kong 428
Ashburn 375
Dallas 239
San Jose 229
Shanghai 171
Hefei 158
Lawrence 142
Princeton 142
Lauterbourg 141
Beijing 133
Ho Chi Minh City 117
Milan 102
Hanoi 69
New York 68
Los Angeles 67
The Dalles 60
São Paulo 59
Nuremberg 40
Helsinki 36
Warsaw 35
Boardman 32
Orem 32
Rome 32
Denver 27
Santa Clara 26
Munich 23
Belo Horizonte 20
Stockholm 19
Vienna 19
Atlanta 18
Cesano Boscone 17
Dublin 17
Montreal 17
Amsterdam 16
Houston 15
London 15
Rio de Janeiro 15
Brooklyn 13
Chennai 13
Florence 13
Manchester 13
São José dos Campos 13
Accra 12
Council Bluffs 12
Guangzhou 12
Biên Hòa 11
Johannesburg 11
Phoenix 11
Poplar 11
Seattle 11
Shenzhen 11
Brasília 10
Frankfurt am Main 10
Mexico City 10
Porto Alegre 10
Pune 10
Tianjin 10
Curitiba 9
Da Nang 9
Haiphong 9
Quito 9
San Francisco 9
Boston 8
Jiaxing 8
Pelotas 8
Querétaro 8
Salvador 8
Thái Bình 8
Toronto 8
Xi'an 8
Chicago 7
Erbil 7
Ha Long 7
Meda 7
Mumbai 7
Tashkent 7
Tokyo 7
Baghdad 6
Barnet 6
Campinas 6
Columbus 6
Fortaleza 6
Heidelberg 6
Mainz 6
Manaus 6
Thái Nguyên 6
Wuxi 6
Bogotá 5
Buenos Aires 5
Changsha 5
Dhaka 5
Goiânia 5
Guarulhos 5
Guayaquil 5
La Plata 5
Lappeenranta 5
Naples 5
New Delhi 5
Totale 4.598
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Nome #
Therapeutic potential of co-signaling receptor modulation in hepatitis B 183
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination 167
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion 166
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models 164
CD4+T cells license Kupffer cells to produce IL-27 and reverse the CD8+T cell dysfunction induced by hepatocellular priming 161
Immunobiology and pathogenesis of hepatitis B virus infection 149
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators 148
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming 135
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses 128
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. 128
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming 117
Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses 111
Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability 109
Bone marrow as an alternative site for islet transplantation 106
Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens 105
Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets 103
Effector CD8+T cell-derived interleukin-10 enhances acute liver immunopathology 102
Inflammatory monocytes hinder antiviral B cell responses 101
Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma 101
Extracellular HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV pathogenesis 101
Immunosurveillance of the liver by intravascular effector CD8+ T cells 100
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection 99
Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans 96
CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming 95
Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus 92
Bone marrow as an alternative site for islet transplantation 91
Altered helper T lymphocyte (HTL) function associated with chronic HBV infection and its role in response to therapeutic vaccination in humans 91
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen 90
A two hit model of CTL killing in vivo 89
Bisphosphonates Target B Cells to Enhance Humoral Immune Responses 89
Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier 88
T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses 86
Role of CCL2/MCP-1 in islet transplantation 85
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice 85
Immunological insights in the treatment of chronic hepatitis B 85
Breaking tolerance leads to autoantibody production but not autoimmune liver-disease in hepatitis-B virus envelope transgenic mice 83
Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice 81
A global scientific strategy to cure hepatitis B 80
Activated intrahepatic antigen presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice 76
In vivo flow mapping in complex vessel networks by single image correlation 74
Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4(+) T Cell Help 73
Platelets mediate cytotoxic T lymphocyte-induced liver damage 73
Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes 72
Analysis of a successful immune response against HBV 71
Preclinical assessment of capsid assembly modulators (CAMs) of varying potency revealed a novel class of picomolar-acting CAMs inducing neither significant HBcAg cytoplasmic retention nor adverse interactions with HBcAg-specific adaptive immunity 71
IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment 70
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis 68
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs 67
Cytotoxic T-lymphocytes inhibit hepatitis-B virus gene-expression by a noncytolytic mechanism in transgenic mice 66
Inhibitors of hepatitis B virus 66
Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells 65
Pathogenesis of hepatitis B virus in transgenic mice 64
Protective and Pathogenic T Cell Responses to Virus Infections 64
Modulation of Early Inflammatory Reactions to Promote Engraftment and Function of Transplanted Pancreatic Islets in Autoimmune Diabetes 64
Platelets mediate cytotoxic T lymphocyte-induced liver damage 62
Is it time to recommend low-dose aspirin treatment for the prevention of hepatocellular carcinoma? 61
Cyclic inhibitors of hepatitis B virus 60
Platelets mediate CTL-induced immunopathology in the liver 59
CTL-induced liver disease requires co-stimulation of both the Fas ligand- and perforin-activated death pathways 59
The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver 59
Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation 59
Tricyclic inhibitors of hepatitis B virus 59
A rapid and robust luciferase-based reporter system to assess SARS-CoV-2 protease activity 58
CTL access to tissue antigen is restricted in-vivo 58
The transgenic mouse model of hepatitis B virus infection 58
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus 57
T helper-1 lymphocytes mediate liver disease in hepatitis B virus transgenic mice 57
HBV pathogenesis in animal models: Recent advances on the role of platelets 57
Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes 57
Hepatitis-B virus nucleocapsid particles do not cross the hepatocyte nuclear-membrane in transgenic mice 57
Cytokine-mediated control of viral infections 57
Effector CD8 T cell trafficking within the liver 57
Pathogenetic and antiviral immune responses against hepatitis B virus 56
The optimization of helper T lymphocyte (HTL) function in vaccine development 56
Editorial overview: Viral pathogenesis 56
HBV Immunopathogenesis 56
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance 55
Liver gene expression associated with the inhibition of HBV replication or transcription 55
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes 55
Mechanisms of class-I restricted immunopathology - a transgenic mouse model of fulminant-hepatitis 54
Cytotoxic T-lymphocytes can clear hepatitis-B virus from the hepatocyte without killing the cell 54
Mouse models of hepatitis B virus pathogenesis 54
Microcirculation in the murine liver: a computational fluid dynamic model based on 3D reconstruction from in vivo microscopy 54
Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich Syndrome patients 54
Class-I restricted cytotoxic T-lymphocytes are directly cytopathic for their target-cells in-vivo 54
Naive HIV/HCV-coinfected patients have higher intrahepatic pro-inflammatory cytokines than coinfected patients treated with antiretroviral therapy 53
High-level hepatitis-B virus-replication in transgenic mice 53
Hepatitis C virus core and E2 protein expression in transgenic mice 53
Host-virus interactions during malaria infection in hepatitis B virus transgenic mice 53
Kupffer cells reduce liver immunopathology 52
The hepatitis B virus X protein transactivates viral core gene expression in vivo 52
Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice 52
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus 51
Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis 51
Update of the statements on biology and clinical impact of occult hepatitis B virus infection 51
Scientific and medical evidence informing expansion of hepatitis B treatment guidelines 50
Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice 50
Cytotoxic T-lymphocyte mediated regulation of hepatitis-B virus gene-expression in-vivo 49
On the role of platelets in the pathogenesis of viral hepatitis 49
TIE2-expressing monocytes regulate revascularisation of the ischaemic limb 49
Totale 7.826
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Categoria #
all - tutte 64.578
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 64.578
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022121 0 0 0 57 2 0 6 3 5 7 5 36
2022/2023846 302 200 62 2 13 118 21 78 31 1 4 14
2023/2024419 22 16 59 114 29 37 13 29 4 10 31 55
2024/20252.003 264 20 15 59 85 161 261 263 348 194 154 179
2025/20266.787 434 433 469 1.049 528 218 521 521 1.999 343 218 54
Totale 10.282